The lab’s research focus is on understanding the constellation of dementia risk factors, ranging from genetic vulnerabilities to neuroimaging biomarkers and psychosocial contributors of cognitive decline and neurodegenerative diseases. Our interdisciplinary neurocognitive ageing research has been published in multiple fields, including cognitive neuroscience, neurology, psychiatry, radiology, cardiology, and gerontology, reflecting the nature of dementia as a multifactorial and heterogeneous disease.
1. Genetics
- Tan CH, Bonham LW, Fan CC, et al. Polygenic Hazard Score, Amyloid Deposition and Alzheimer’s Neurodegeneration. Brain. 2019;142(2):460-470.
- Tan CH, Fan CC, Mormino EC, et al. Polygenic hazard score: an enrichment marker for Alzheimer’s associated amyloid and tau deposition. Acta Neuropathol. 2018; 135(1):85-93
- Tan CH, Hyman BT, Tan JJX, et al. Polygenic hazard scores in preclinical Alzheimer disease. Ann Neurol. 2017; 82(3):484-488.
2. Cerebrovascular disease
- Tan CH, Chew JLH, Zhang L, et al. Differential Effects of White Matter Hyperintensities and Regional Amyloid Deposition on Regional Cortical Thickness. Neurobiol Aging. 2022;115:12-19
- Tan CH, Low KA, Chiarelli AM, et al. Optical Measures of Cerebral Arterial Stiffness are Associated with White Matter Signal Abnormalities and Cognitive Decline in Aging. Neurobiol Aging. 2019;84:200-207.
- Tan CH, Low KA, Kong T, et al. Mapping cerebral pulse pressure and arterial compliance over the adult lifespan with optical imaging. PLoS One. 2017; 12(2):e0171305.
3. Psychological disorders and Neuropsychiatry
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- Kan CN, Coenen M, Xin X, …Tan CH. Tract-specific white matter hyperintensities and neuropsychiatric syndromes: a multi-center memory clinic study. J Neurol Neurosurg Psychiatry (in press)
- Kan CN, Xu X, Venketaubramanian N, … Tan CH. Interactions of Comorbid Neuropsychiatric Subsyndromes with Neurodegenerative and Cerebrovascular Pathologies on Cognition. Neurobiol Aging 2022;109:239-246
4. Socioeconomic Status
- Tan CH, Tan JJX. Associations of Cardiac Function and Arterial Stiffness with Cerebrovascular Disease. Int J Cardiology. 2024; 407:132037
- Tan CH, Tan JJX. Low Neighborhood Deprivation buffers against Hippocampal Neurodegeneration, White Matter Hyperintensities, and poorer Cognition. Geroscience. 2023; 45:2027-2036