Publication

  1. Qiao Z, Do PH, Yeo JY, Ero R, Li Z, Zhan L, Basak S, Gao YG, “Structural insights into polyamine spermidine uptake by the ABC transporter PotD-PotABC”, Science Advances, 2024, 10(38):eado8107. doi: 10.1126/sciadv.ado8107
  2. Lin J, Yan X, Chung Z, Liew CW, El Sahili A, Pechnikova EV, Preiser PR, Bozdech Z, Gao YG, Lescar J, “Inhibition of falcilysin from Plasmodium falciparum by interference with its closed-to-open dynamic transition“, Commun Biol., 2024 Aug 31;7(1):1070. doi: 10.1038/s42003-024-06774-6.
  3. Tan KA, Qiao Z, Lim ZZE, Yeo JY, Yong Y, Do PH, Ero R, Gao YG, “Cryo-EM strcutre of the SPFH-NfeD family protein complex QmCA-YbbJ”, Structure, 2024, Aug 13:S0969-2126(24)00285-5. doi.org/10.1016/j.str.2024.07.022.
  4. Ma GL, Liu WQ, Huang H, Yan XF, Shen W, Visitsatthawong S, Prakinee K, Tran H, Fan X, Gao YG ,Chaiyen P, Li J, Liang ZX, “An Enzymatic Oxidation Cascade Converts δ-Thiolactone Anthracene to Anthraquinone in the Biosynthesis of Anthraquinone-Fused Enediynes”, JACS Au, 2024, Aug 9; 4(8):2925-2935. doi: 10.1021/jacsau.4c00279.
  5. Kalailingam P, Mohd-Kahliab KH, Ngan SC, Iyappan R, Melekh E, Lu T, Zien GW, Sharma B, Guo T, MacNeil AJ, MacPherson RE, Tsiani EL, O’Leary DD, Lim KL, Su IH, Gao YG, Richards AM, Kalaria RN, Chen CP, McCarthy NE, Sze SK, “Immunotherapy targeting isoDGR-protein damage extends lifespan in a mouse model of protein deamidation”, EMBO Mol Med., 2023 Dec 7;15(12):e18526. doi: 10.15252/emmm.202318526.
  6. Shen X, Yang Z, Li Z, Xiong D, Liao J, He W, Shen D, Shao X, Niu B, He Y, Gao YG, Qian G, “Identification of atypical T4SS effector proteins mediating bacterial defense”, mLife, 2023, 2(3): 295-307.
  7. Liang Z, Lin Q, Wang Q, Huang L, Liu H, Shi Z, Cui Z, Zhou X, Gao YG, Zhou J, Zhang LH, Deng Y, “Gram-negative bacteria resist antimicrobial agents by a DzrR-mediated envelope stress response”, BMC Biol., 2023 Mar 29;21(1):62. doi: 10.1186/s12915-023-01565-7.
  8. Vinaiphat A, **Pazhanchamy K, JebaMercy G, Ngan SC, Leow MK, Ho HH, Gao YG, Lim KL, Richards AM, de Kleijn DPV, Chen CP, Kalaria RN, Liu J, O’Leary DD, McCarthy NE, Sze SK, “Endothelial damage arising from high salt hypertension is elucidated by vascular bed systematic profiling”, Arterioscler Thromb Vasc Biol.,2023 Mar;43(3):427-442. doi: 10.1161/ATVBAHA.122.318439.
  9. Qiao Z, Kong Q, Tee WT, Lim ARQ, Teo MX, Olieric V, Low PM, Yang Y, Qian G, Ma W, Gao YG, “Molecular basis of the key regulator WRINKLED1 in plant oil biosynthesis”, Science Advances, 2022, 8(34): eabq1211. doi: 10.1126/sciadv.abq1211.
  10. Datta A, Chen C, Gao YG, Sze SK, “Quantitative proteomics of medium-sized extracellular vesicle-enriched plasma of lacunar infarction for the discovery of prognostic biomarkers”, Int J Mol Sci, 2022, 23(19):11670. doi: 10.3390/ijms231911670.
  11. Ma Z, Zhu K, Gao YG, Tan SM, Miao Y, “Molecular condensation and mechanoregulation of plant class I formin, an integrin-like actin nucleator”, FEBS Journal, 2022, doi: 10.1111/febs.16571.
  12. Qiao Z, Yokoyama T, Yan XF, Beh IT, Shi J, Basak S, Akiyama Y, Gao YG, “Cryo-EM structure of the entire FtsH-HflKC AAA protease complex”, Cell Reports, 2022, 39(9):110890. doi: 10.1016/j.celrep.2022.110890.
  13. Yan XF, Yang C, Wang M, Yong Y, Deng Y, Gao YG, “Structural basis of the AAA+ ATPase domain of the transcriptional regulator GtrR in the DBSF quorum-sensing system in Burkholderia cenocepacia”, FEBS Letters, 2022, 596(1):71-80. doi:10.1002/1873-3468.14244
  14. Jiang Z, Hu S, Ma J, Liu Y, Qiao Z, Yan Q, Gao YG, Yang S, “Crystal structure of a chitinase (RmChiA) from the thermophilic fungus Rhizomucor miehei with a real active site tunnel”, Biochim Biophys Acta Proteins Proteom., 2021,1869(11):140709. doi:10.1016/j.bbapap.2021.140709.
  15. Goh WJ, Ero R, Yan XF, Park JE, Kundukad Binu, Zheng J, Sze SK, Gao YG, “Translational GTPase BipA is involved in the maturation of large subunit of bacterial ribosome at suboptimal temperature”, Front Microbiol., 2021,12: 686049. doi: 3389/fmicb.2021.686049.
  16. Zhao K, Ke Z, Hu H, Liu Y, Li A, Hua R, Guo F, Xiao J, Zhang Y, Duan L, Yan XF, Gao YG, Liu B, Xia Y, Li Y, “Structural Basis and Function of the N Terminus of SARS-CoV-2 Nonstructural Protein 1 mediated protein translation”, Microbiol Spectr., 2021, 16:e0016921. doi: 10.1128/Spectrum.00169-21
  17. Ero R, Yan XF, Gao YG, “Ribosome Protection Proteins-“New” Players in the Global Arms Race with Antibiotic-Resistant Pathogens”, Int J Mol Sci., 2021, 22(10):5356. doi: 10.3390/ijms22105356
  18. Bu W, Levitskaya Z, Tan SM, Gao YG, “Emerging evidence for kindlin oligomerization and its role in regulating kindlin function”, J Cell Sci.,2021,134(8):jcs256115. doi: 10.1242/jcs.256115.
  19. Ooi KH, Liu MM, Tay JWD, Teo SY, Kaewsapsak P, Jin S, Lee C, Hou J, Mauer-Stroh S, Lin W, Yan B, Yan G, Gao YG, Tan MH, “An engineered CRISPR-Cas12a variant and DNA-RNA hybrid guides enable robust and rapid COVID-19 testing”, Nat Commun, 2021, 12(1): 1739. Doi: 10.1038/s41467-021-21996-6.
  20. Qiao Z, Lampugnani E, Yan XF, Khan AG, Saw WG, Hannah P, Qian F, Calabria J, Miao Y, Gruber G, Persson S, Gao YG, “Structure of Arabidopsis CESA3 catalytic domain with its substrate UDP-glucose provides insight into the mechanism of cellulose synthesis”, PNAS, 2021, 118(11):e2024015118. Doi:10.1073/pnas.2024015118.
  21. Xie Y, Loh ZY, Xue J, Zhou F, Sun J, Qiao Z, Jin S, Deng Y, Li H, Wang Y, Lu L, Gao YG, Miao Y, “Orchestrated actin nucleation by the Candida albicans polarisome complex enables filamentous growth”, J Biol Chem, 2020, 295(44): 14840-14854.
  22. *Ye F, Wang C, *Fu Q, *Yan XF, Bharath S, Casanas A, Wang M, Song H, Zhang LH, Gao YG, “Structural basis of a novel repressor SghR controlling Agrobacterium infection by cross-talking to plants”, J Biol Chem, 2020, 295(34): 12290-12304.
  23. Bu W, Levitskaya Z, Loh ZY, Jin S, Basu S, Ero R, Yan XF, Wang M, Ngan S, Sze SK, Tan SM, Gao YG, “Structural basis of human full-length kindlin-3 homotrimer in an auto-inhibited state”, Plos Biology, 2020, 18(7): e3000755.
  24. Jin S, Vullo D, Bua S, Nocentini A, Supuran CT, Gao YG, “Structural and biochemical characterization of novel Phaeodactylum tricornutum”, Acta Crystallogr D Struct Biol. 2020,76(Pt 7):676-686.
  25. Han S, Shen D, Wang YC, Chou SH, Gomelsky M, Gao YG, Qian G, “A YajQ-LysR-like, cyclic di-GMP-dependent system regulating biosynthesis of an antifungal antibiotic in a crop-protecting bacterium, Lysobacter enzymogenes”, Mol Plant Pathol., 2020, 21(2):218-229.
  26. He Q, Toh JD, Ero R, Qiao Z, Kumar V, Serra A, Tan J, Sze SK, Gao YG, “The unusual di-domain structure of Dunaliella salina glycerol-3-phosphate dehydrogenase enables direct conversion of dihydroxyacetone phosphate to glycerol”, Plant J., 2020, 102(1): 153-1642.
  27. Tsai YC, Ye F, Liew L, Liu D, Bhushan S, Gao YG†, Mueller-Cajar O, “Insights into the mechanism and regulation of the CbbQO-type Rubisco activase, a MoxR AAA+ ATPase”, PNAS, 2020, 117(1):381-387.
  28. Qiao Z, Sun H, Ng JTY, Ma Q, Koh SH, Mu Y, Miao Y, Gao YG, “Structural and computational examination of the Arabidopsis profilin-Poly-P complex reveals mechanistic details in profilin-regulated actin assembly”, J Biol Chem.,2019, 294(49): 18650-18661.
  29. Xie Y, Sun J, Han X, Turšić-Wunder A, Toh JDW, Hong W, Gao YG†, Miao Y†, “Polarisome scaffolder Spa2-mediated macromolecular condensation of Aip5 for actin polymerization”, Nat Commun,2019, 10(1): 5078.
  30. Wang C*, Ye F*, Chang C, Liu X, Fu Q, Zhou J, Tang D, Chen S, Gao YG†, Zhang LH†, “Agrobacteria reprogram virulence gene expression by controlled release of host conjugated defense signals”, PNAS, 2019, 116(44): 22331-22340 (a recommended article by Faculty of 1000).
  31. Gallart-Palau X, Tan LM, Serra A, Gao YG, Ho HH, Richards AM, Kandiah N, Chen CP, Kalaria RN, Sze SK, “Degenerative protein modifications in the aging vasculature and central nervous system: A problem shared is not always halved”, Ageing Res Rev, 2019, 53: 100909.
  32. Ero R, Kumar V, Su WX, Gao YG, “Ribosome protection by ABC-F proteins-molecular mechanism and potential drug design”, Protein Science(Cover Image), 2019, 28(4): 684-693.
  33. Konarzewska P, Wang Y, Han GS, Goh KJ, Gao YG, Carman GM, Xue C, “Phosphatidylserine synthesis is essential for viability in the human fungal pathogen Cryptococcus neoformans”, J Biol Chem, 2019, 294(7): 2329-2339.
  34. Koh CWQ, Goh YT, Toh JDW, Neo SP, Ng SB, Gunaratne J, Gao YG, Quakw SR, Burkholder WF, Goh WSS, “Single-nucleotide-resolution sequencing of human N6-methyldeoxyadenosine reveals strand-asymmetric clusters associated with SSBP1 on the mitochondrial genome”, Nucleic Acids Research, 2018, 46(22): 11659-11670. (NAR Breakthrough Article).
  35. Sun H, Qiao Z, Chua KP, Tursic A, Liu X, Gao YG, Mu Y, Hou X, Miao Y, “Profilin negatively regulates formin-mediated actin assembly to modulate PAMP-triggered plant immunity”, Current Biology, 2018, 28(12): 1882-1895.
  36. Su WX, Kumar V, Ding Y, Ero R, Serra A, Lee ST, Wong AS, Shi J, Sze SK, Yang L, Gao YG, “Ribosome protection by antibiotic resistance ATP-binding cassette protein”,PNAS, 2018, 115(20):5157-5162 (Recommend article by F1000).
  37. Yan XF, Xin L, Yen JT, Zeng Y, Jin S, Cheang QW, Fong RACY, Chiam KH, Liang ZX, Gao YG,“Unravel the molecular mechanism of cyclic di-GMP regulation of bacterial chemotaxis via a PilZ adaptor protein”, J Biol Chem, 2018, 293(1): 100-111.
  38. Puah RY*, Jia H*, Maraswami M*, Toh DFK*, Ero R*, Yang L, Patil K, Ong AAL, Krishna M, Sun R, Tong C, Huang M, Chen X, Loh TP, Gao YG, Liu DX, Chen G, “Selective Binding to mRNA Duplex Regions by Chemically Modified PNAs Stimulates Ribosomal Frameshifting”, Biochemistry,2018, 57(1):149-159.
  39. Yang C, Cui C, Ye Q, Kan J, Song S, Huang Y, Fu S, He F, Zhang LH, Jia Y, Gao YG, Harwood C, Deng Y, “Cis-2-dodecenonic acid quorum sensing signal receptor RpfR modulates virulence by sending to cyclic diguanosine monophosphate in Burkholderia cenocepacia”, PNAS, 2017, 114 (49): 13006-13011.
  40. Xu L, Liu X, Oo K, Liang J, Ye F, Chionh Y, Xu J, Sheng N, Gao YG, Dedon P, Fu XY, “Division of labor for 3-methylcytidine formation by methyltransferase-like 2 and 6 in humans and mice”, J Biol Chem, 2017, 292(35): 14695-14703.
  41. Jin S, Sun J, Wunder T, Tang D, Cousins AB, Sze S, Mueller-Cajar O, Gao YG, “Structural insights into the LCIB protein family reveals a new group of β-carbonic anhydrases”, PNAS,2016, 112 (51): 14716-14721.
  42. Ero R, Kumar V, Chen Y, Gao YG, “Similarity and diversity of translational GTPase factors EF-G, EF4, and BipA: from structure to function”, RNA Biology, 2016, 13(12): 1258-1273.
  43. Kumar V, Ero R, Ahmed T, Goh KJ, Zhao Y, Bhushan S, Gao YG, “The structure of elongation factor 4 (EF4/LepA) in GTP form bound to the ribosome”, J Biol Chem(Cover Image) 2016, 291: 12943-50.
  44. Zhou S*, Toh JDW*, Wong KHQ, Gao YG, Hong W, Woon ECY, “N6-Methyladenosine: a conformational marker that regulates the substrate specificity of human demethylases FTO and ALKBH5”, Scientific Reports, 2016, 6: 25677.
  45. Wang C, Tang D, Gao YG, Zhang LH, “Succinic semialdehyde promotes Pro-survival capability of Agrobacterium tumefaciens”, J Bacteriol., 2016, 198(6):930-40.
  46. Qu J*, Ero R*, Feng C, Ong LT, Tan HF, Ismail MH, Bu WT, Nama S, Sampth P, Gao YG†, Tan SM†, “Kindlin-3 interacts with the ribosome and regulates c-Myc expression required for proliferation of chronic myeloid leukemia cells”, Scientific Reports, 2015, 5: 18491.
  47. Ye F, Wang C, Fu Q, Zhang LH, Gao YG, “Cloning, expression, purification and crystallization of a pair of novel virulence factors, SghA and SghR, from Agrobacterium tumefaciens”, Acta Crystallogr F Struct Biol Commun,2015, 71(Pt 9): 1139-45.
  48. Kumar V, Chen Y*, Ero R*, Ahmed T*, Tan J, Li Z, Wong AS, Bhushan S, Gao YG, “Structure of BipA in GTP form bound to the ratcheted ribosome”, PNAS, 2015, 112 (35): 10944-9.
  49. Wang C, Yan C, Gao YG†, Zhang L†, “D101 is critical for the function of AttJ, a repressor of quorum quenching system in Agrobacterium tumefaciens”, J Microbio, 2015, 53 (9): 623-32.
  50. Yu Y, Wu Y, Cao B, Gao YG†, Yan X†, “Adjustable bidirectional extracellular electron transfer between Comamonas testosteroni biofilms and electrode via distinct electron mediators”, Electrochemistry Communications, 2015, 59: 43-47.
  51. Ero R, Dimireova VT, Chen Y, Bu W, Feng S, Liu T, Wang P, Xue C, Tan SM, Gao YG, “Crystal structure of Gib2, a signal-transducing protein scaffold associated with ribosome in Cryptococcus neoformans”, Scientific Reports, 2015, 5:8688. doi:10.1038/srep08688.
  52. Toh DW*, Sun L*, Lau ZM, Tan J, Low JA, Tang WQ, Cheong JY, Tan JH, Chen Y, Hong W, Gao YG†, Woon ECY†, “A strategy based on nucleotide specificity leads to subfamily-selective and cell-active probe of N6-methyladenosine demethylase FTO”, Chemical Science, (Cover Image) 2015, 6(1): 112-122 (dio:10.1039/CASC02554G).
  53. Wang C*, Ye F*, Kumar V, Gao YG†, Zhang LH†, “BswR controls bacterial motility and biofilm formation in Pseudomonas aeruginosathrough modulation of the small RNA rsmZ”, Nucleic Acids Research, 2014, 42(7): 4563-4576. doi: 10.1093/nar/gku106. Epub 2014 Feb 3.
  54. Feng S*, Chen Y*, Kamada K, Wang H, Tang K, Wang M, Gao YG,“ YoeB–ribosome structure: A canonical RNase that requires the ribosome for its specific activity”, Nucleic Acids Research, 2013, 41(20): 9549-9556. doi: 10.1093/nar/gkt742. Epub 2013 Aug 14.
  55. Chen Y, Feng S, Kumar V, Ero R, Gao YG, “Structure of EF-G-Ribosome complex in a pretranslocation state”, Nature Structural & Molecular Biology, 2013, 20: 1077-1084 (online on 4 August 2013, doi: 10.1038/nsmb.2645); Highlighted under New and Views in Nature Structural & Molecular Biology, 2013, 20: 1019-1022.
  56. Feng S*, Chen Y*, Gao YG, “Crystal structure of 70S ribosome with both cognate tRNAs in the E and P sites representing an authentic elongation complex”, PLOS ONE, 2013, 8(3): e58829.
  57. Ariyawutthiphan O, Ose T，Minami A, Sinde S, Tsuda M, Gao YG, Yao M, Oikawa H, Tanaka I, “Structure analysis of geranyl pyrophosphate methyltransferase and the proposed reaction mechanism of SAM-dependent C-methylation”, Acta Crystallographica Section D, (Cover Image)2012, 68 (11):  1558-1569.
  58. Selmer M*, Gao YG*, Weixlbaumer A, Ramakrishnan V, “Ribosome engineering to promote new crystal forms”, Acta Crystallographica Section D, 2012, 68 (5): 578-583.
  59. Ariyawutthiphan O, Ose T, Teuda M, Gao YG, Yao M, Minami A, Oikawa H, Tanaka I, “Crystallization and preliminary X-ray crystallographic study of a methyltransferase involved in 2-methylisoborneol biosynthesis in Streptomyces lasaliensis”, Acta Crystallogra Sect F Struct Biol Cryst Commun. 2011, 67(3): 417-420.
  60. Hu SQ*, Gao YG*, Tajima K*, Sunagawa N, Zhou Y, Kawano S, Yoda T, Shimura D, Satoh Y, Munekata M, Tanaka I, Yao M, “Structure of bacterial cellulose synthase subunit D octamer with four inner passageways”, PNAS, 2010, 107(42): 17957-17961. (Comment in Nature Chemical Biology: 2010 Vol6, 883-884)
  61. Neubauer C*, Gao YG*, Andersen KR*, Dunham CM, Kelley A, Hentschel J, Gerdes K, Ramakrishnan V, Brodersen D, “The structural basis for mRNA cleavage by the ribosome-dependent endonuclease RelE”, Cell, (Cover image) 2009, 139 (6): 1084-1095.
  62. Gao YG, Selmer M, Dunham C, Weixlbaumer A, Kelley AC, Ramakrishnan V, “The structure of the ribosome with elongation factor G trapped in the post-translocational state”, Science (Article, Cover image) 2009, 326: 694-699. (Comment in Science2009 326:677-678).
  63. Schmeing TM*, Voorhees RM*, Kelley AC, Gao YG, Murphy FV IV, Weir JR, Ramakrishnan V, “The crystal structure of the ribosome bound to EF-Tu and aminoacyl-tRNA”, Science(Article, Cover image) 2009, 326: 688-694. (Comment in Science 2009 326:677-678).
  64. Gao YG, Suzuki H, Itou H, Wachi M, Watanabe N, Tanaka I, Yao M, “Structural and functional characterization of the LldR from Corynebacterium glutamicum: a transcriptional repressor involved in L-lactate and sugar utilization”,Nucleic Acids Research, 2008, 36: 7110-7123.
  65. Begum P, Sakai N, Hayashi T, Gao YG, Tamura T, Watanabe N, Min Yao, Tanak I, “Crystal structure of SCO6571 from Streptomyces coelicolorA3(2)”, Protein & Peptide Letters, 2008, 15(7):709-12 
  66. Yoshikazu T, Sakamoto S, Kuroda M, Goda S, Gao YG, Tsumoto K, Hiragi Y, Yao M, Watanabe N, Ohta T, Isao Tanaka I, “A helical string of alternately connected two-three helix bundles for the 1.1-megadalton cell wall-associated adhesion protein Ebh from Staphylococcus aureus”, Structure, 2008, 16: 488-496.
  67. Gao YG,Yao M, Tanaka I, “The structure of protein PH0536 from Pyrococcus horikoshii at 1.7 Å resolution reveals a novel assembly of an oligonucleotide / oligosaccharide-binding fold and an a-helices bundle”, Proteins, 2008, 71: 503-508.
  68. Hu SQ, Gao YG, Tajima K, Yao M, Yoda T, Shimura D, Satoh Y, Shin Kawano, Tanaka I, Munekata M, “Purification, crystallization and preliminary x-ray studies of AxCesD required for efficient cellulose biosynthesisin Acetobacter xylinum”, Protein & Peptide Letters, 2008, 15: 115-117.
  69. Gao YG,Yao M, Itou H, Zhou Y, Tanaka I, “The structures of transcription factor CGL2947 from Corynebacterium glutamicum in two crystal forms: a novel homodimer assembling and the implication for effector-binding mode”, Protein Science, 2007, 16 (9): 1878-1886.
  70. Gao YG,Yao M, Okada A, Tanaka I, “The structure of Pyrococcus horikoshii 2′-5′ RNA ligase at 1.94 Å resolution reveals a possible open form with a wider active-site cleft”, Acta Crystallographica Section F, 2006, 62 (12): 1196-1200.
  71. Gao YG, Yao M, Zhou Y, Tanaka I, “crystal structure of the putative methyltransferase PH1948 from Pyrococcus horikoshii, in complex with the co-purified S-adenosyl-L-homocysteine”,Proteins, 2005, 61(4): 1141-1145.
  72. Gao YG, Yao M, Tanaka I, “Preparation, crystallization and preliminary X-ray diffraction analysis of PH1948, predicted RNA methyltransferase from Pyrococcus horikoshii”,J Zhejiang Univ Sci B., 2005, 6 (6): 454-456.
  73. Guan YX, Pan HX, Gao YG, Yao YJ, Cho, MG “Refolding and purification of recombinant human interferon-gamma expressed as inclusion bodies in Escherichia coliusing size exclusion chromatography”, Biotechnology and Bioprocess Engineering, 2005,10 (2): 122-127.
  74. Gao YG, Guan YX, Yao SJ, Cho MG, “On-column refolding of recombinant human interferon-gamma assisted with an immobilized chaperone fragment”.Biotechnology Progress, 2003, 19(3): 915-20.
  75. Gao YG, Guan YX, Yao SJ, Cho MG, “Lysozyme refolding at high concentration by dilution and size exclusion chromatography”. J Zhejiang Univ Sci., 2003, 4(2):136-141.
  76. Gao YG, Guan YX, Yao SJ, “Refolding of lysozyme at high concentration in batch and fed-batch operation”.Korean Journal of Chemical Engineering, 2002, 19 (5), 871~875.