Author: lowct

Publications

Year 2000 – 2005

  1. Ng KW, Tham W, Lim TC,Hutmacher DW. Assimilating cell sheets and hybrid scaffolds for dermal tissue engineering. Journal of Biomedical Materials Research – Part A 75, 425-438, (2005) [https://doi.org/10.1002/jbm.a.30454].
  2. Ng KW, Louis J, Tuan Ho BS, Achuth HN, Lu J, Moochhala S, Lim TC,Hutmacher DW. Characterization of a novel bioactive poly[(lactic acid)-co-(glycolic acid)] and collagen hybrid matrix for dermal regeneration. Polymer International 54, 1449-1457, (2005) [https://doi.org/10.1002/pi.1868].
  3. Ng KW, Leong DTW,Hutmacher DW. The challenge to measure cell proliferation in two and three dimensions. Tissue Engineering 11, 182-191, (2005) [https://doi.org/10.1089/ten.2005.11.182].
  4. Ng KW, Louis J, Tham WR, Achuth HN, Lim TC, Moochhala S,Hutmacher DW. A textile mesh-collagen hybrid matrix and cell sheet technology for skin tissue engineering C3 – Transactions – 7th World Biomaterials Congress. 412, (2004)
  5. Ng KW, Khor HL,Hutmacher DW. In vitro characterization of natural and synthetic dermal matrices cultured with human dermal fibroblasts. Biomaterials 25, 2807-2818, (2004) [https://doi.org/10.1016/j.biomaterials.2003.09.058].
  6. Louis J, Ng KW, Achuth HN, Lu J, Moochhala S,Hutmacher DW. An in vivo evaluation of a bioactive composite matrix for dermal regeneration C3 – Transactions – 7th World Biomaterials Congress. 1071, (2004)
  7. Khor HL, Ng KW, Htay AS, Schantz JT, Teoh SH,Hutmacher DW. Preliminary study of a polycaprolactone membrane utilized as epidermal substrate. Journal of Materials Science: Materials in Medicine 14, 113-120, (2003) [https://doi.org/10.1023/A:1022059511261].
  8. Hutmacher DW, Ng KW, Kaps C, Sittinger M,Kläring S. Elastic cartilage engineering using novel scaffold architectures in combination with a biomimetic cell carrier. Biomaterials 24, 4445-4458, (2003) [https://doi.org/10.1016/S0142-9612(03)00350-8].
  9. Schantz JT, Hutmacher DW, Ng KW, Khor HL, Lim TC,Teoh SH. Evaluation of a Tissue-Engineered Membrane-Cell Construct for Guided Bone Regeneration. International Journal of Oral and Maxillofacial Implants 17, 161-174, (2002)
  10. Schantz JT, Hutmacher DW, Chim H, Ng KW, Lim TC,Teoh SH. Induction of ectopic bone formation by using human periosteal cells in combination with a novel scaffold technology. Cell Transplantation 11, 125-138, (2002) [https://doi.org/10.3727/096020198389852].
  11. Khor HL, Ng KW, Schantz JT, Phan TT, Lim TC, Teoh SH,Hutmacher DW. Poly (ε-caprolactone) films as a potential substrate for tissue engineering an epidermal equivalent. Materials Science and Engineering C 20, 71-75, (2002) [https://doi.org/10.1016/S0928-4931(02)00015-2].
  12. Hutmacher DW, Teoh SH, Zein I, Ng KW, Schantz JT,Leahy JC. Design and fabrication of a 3D scaffold for tissue engineering bone. ASTM Special Technical Publication, 152-167, (2001)
  13. Hutmacher DW, Schantz T, Zein I, Ng KW, Teoh SH,Tan KC. Mechanical properties and cell cultural response of polycaprolactone scaffolds designed and fabricated via fused deposition modeling. Journal of Biomedical Materials Research 55, 203-216, (2001) [https://doi.org/10.1002/1097-4636(200105)55:2<203::AID-JBM1007>3.0.CO;2-7].
  14. Hutmacher DW, Teoh SH, Zein I, Ng KW, Schantz JT,Leahy JC. Design and fabrication of a 3D scaffold for tissue engineering bone C3 – ASTM Special Technical Publication. 152-167, (2000)

Publications

Year 2006 – 2010

  1. Tay CY, Yu H, Pal M, Leong WS, Tan NS, Ng KW, Leong DT,Tan LP. Micropatterned matrix directs differentiation of human mesenchymal stem cells towards myocardial lineage. Experimental Cell Research 316, 1159-1168, (2010) [https://doi.org/10.1016/j.yexcr.2010.02.010].
  2. Heng BC, Zhao X, Xiong S, Woei Ng K, Yin-Chiang Boey F,Say-Chye Loo J. Toxicity of zinc oxide (ZnO) nanoparticles on human bronchial epithelial cells (BEAS-2B) is accentuated by oxidative stress. Food and Chemical Toxicology 48, 1762-1766, (2010) [https://doi.org/10.1016/j.fct.2010.04.023].
  3. Heng BC, Das GK, Zhao X, Ma LL, Tan TTY, Ng KW,Loo JSC. Comparative cytotoxicity evaluation of lanthanide nanomaterials on mouse and human cell lines with metabolic and DNA-quantification assaysa. Biointerphases 5, 88-97, (2010) [https://doi.org/10.1116/1.3494617].
  4. Szeverenyi I, Cassidy AJ, Cheuk WC, Lee BTK, Common JEA, Ogg SC, Chen H, Shu YS, Goh WLP, Kee WN, Simpson JA, Li LC, Goi HE, Li B, Lunny DP, Chuon D, Venkatesh A, Kian HK, McLean WHI, Yun PL,Lane EB. The human intermediate filament database: Comprehensive information on a gene family involved in many human diseases. Human Mutation 29, 351-360, (2008) [https://doi.org/10.1002/humu.20652].
  5. Ng KW, Achuth HN, Moochhala S, Lim TC,Hutmacher DW. In vivo evaluation of an ultra-thin polycaprolactone film as a wound dressing. Journal of Biomaterials Science, Polymer Edition 18, 925-938, (2007) [https://doi.org/10.1163/156856207781367693].
  6. Kee WN, Speicher T, Dombrowski C, Helledie T, Haupt LM, Nurcombe V,Cool SM. Osteogenic differentiation of murine embryonic stem cells is mediated by fibroblast growth factor receptors. Stem Cells and Development 16, 305-318, (2007) [https://doi.org/10.1089/scd.2006.0044].
  7. Ng KW,Hutmacher DW. Reduced contraction of skin equivalent engineered using cell sheets cultured in 3D matrices. Biomaterials 27, 4591-4598, (2006) [https://doi.org/10.1016/j.biomaterials.2006.04.020].

Publications

Year 2011 – 2015

  1. Zhao X, Xiong S, Huang LC, Ng KW,Loo SCJ. Nanoparticle-assay marker interaction: effects on nanotoxicity assessment. Journal of Nanoparticle Research 17, (2015) [https://doi.org/10.1007/s11051-014-2841-0].
  2. Zhao X, Lui YS, Choo CKC, Sow WT, Huang CL, Ng KW, Tan LP,Loo JSC. Calcium phosphate coated Keratin-PCL scaffolds for potential bone tissue regeneration. Materials Science and Engineering C 49, 746-753, (2015) [https://doi.org/10.1016/j.msec.2015.01.084].
  3. Wang X, Sng MK, Foo S, Chong HC, Lee WL, Tang MBY, Ng KW, Luo B, Choong C, Wong MTC, Tong BMK, Chiba S, Loo SCJ, Zhu P,Tan NS. Early controlled release of peroxisome proliferator-activated receptor β/δ agonist GW501516 improves diabetic wound healing through redox modulation of wound microenvironment. Journal of Controlled Release 197, 138-147, (2015) [https://doi.org/10.1016/j.jconrel.2014.11.001].
  4. Wang S, Wang Z, Foo SEM, Tan NS, Yuan Y, Lin W, Zhang Z,Ng KW. Culturing fibroblasts in 3D human hair keratin hydrogels. ACS Applied Materials and Interfaces 7, 5187-5198, (2015) [https://doi.org/10.1021/acsami.5b00854].
  5. Satish R, Vanchiappan A, Wong CL, Ng KW,Srinivasan M. Macroporous carbon from human hair: A journey towards the fabrication of high energy Li-ion capacitors. Electrochimica Acta 182, 474-481, (2015) [https://doi.org/10.1016/j.electacta.2015.09.127].
  6. Liu H, Zhang Z, Toh WS, Ng KW, Sant S,Salgado A. Stem Cells: Microenvironment, Micro/Nanotechnology, and Application. Stem Cells International 2015, 1-2, (2015) [https://doi.org/10.1155/2015/398510].
  7. Kathawala MH, Yun Z, Chu JJH, Ng KW,Loo SCJ. TiO2-nanoparticles shield HPEKs against ZnO-induced genotoxicity. Materials and Design 88, 41-50, (2015) [https://doi.org/10.1016/j.matdes.2015.08.108].
  8. Kathawala MH, Ng KW,Loo SCJ. TiO2 nanoparticles alleviate toxicity by reducing free Zn2+ ion in human primary epidermal keratinocytes exposed to ZnO nanoparticles. Journal of Nanoparticle Research 17, (2015) [https://doi.org/10.1007/s11051-015-3068-4].
  9. Kathawala MH, Khoo SPK, Sudhaharan T, Zhao X, Say Chye Loo J, Ahmed S,Ng KW. Fluorescence techniques used to measure interactions between hydroxyapatite nanoparticles and epidermal growth factor receptors. Biotechnology Journal 10, 171-179, (2015) [https://doi.org/10.1002/biot.201400404].
  10. Hartrianti P, Ling L, Goh LMM, Ow KSA, Samsonraj RM, Sow WT, Wang S, Nurcombe V, Cool SM,Ng KW. Modulating Mesenchymal Stem Cell Behavior Using Human Hair Keratin-Coated Surfaces. Stem Cells International 2015, (2015) [https://doi.org/10.1155/2015/752424].
  11. George S, Ho SS, Wong ESP, Tan TTY, Verma NK, Aitken RJ, Riediker M, Cummings C, Yu L, Wang ZM, Zink D, Ng Z, Loo SCJ,Ng KW. The multi-facets of sustainable nanotechnology-Lessons from a nanosafety symposium. Nanotoxicology 9, 404-406, (2015) [https://doi.org/10.3109/17435390.2015.1027315].
  12. Bhardwaj N, Ting Sow W, Devi D, Woei Ng K, Mandal BB,Cho NJ. Erratum: Silk fibroin-keratin based 3D scaffolds as a dermal substitute for skin tissue engineering (Integrative Biology (United Kingdom) (2015) DOI: 10.1039/c4ib00208c). Integrative Biology (United Kingdom) 7, 142, (2015) [https://doi.org/10.1039/c4ib90045f].
  13. Bhardwaj N, Sow WT, Devi D, Ng KW, Mandal BB,Cho NJ. Silk fibroin-keratin based 3D scaffolds as a dermal substitute for skin tissue engineering. Integrative Biology (United Kingdom) 7, 53-63, (2015) [https://doi.org/10.1039/c4ib00208c].
  14. Low YKA, Zou X, Fang YM, Wang JL, Lin WS, Boey FYC,Ng KW. β-Phase poly(vinylidene fluoride) films encouraged more homogeneous cell distribution and more significant deposition of fibronectin towards the cell-material interface compared to α-phase poly(vinylidene fluoride) films. Materials Science and Engineering C 34, 345-353, (2014) [https://doi.org/10.1016/j.msec.2013.09.029].
  15. Leong DT,Ng KW. Probing the relevance of 3D cancer models in nanomedicine research. Advanced Drug Delivery Reviews 79, 95-106, (2014) [https://doi.org/10.1016/j.addr.2014.06.007].
  16. Zhao Y, Ma X, Qu Q, Zhao Y, Luo Z, Zhao Y,Ng KW. Graphene oxide wrapped gold nanoparticles for intracellular Raman imaging and drug delivery. Journal of Materials Chemistry B 1, 6495-6500, (2013) [https://doi.org/10.1039/c3tb21385d].
  17. Zhao Y, Howe JLC, Yu Z, Leong DT, Chu JJH, Loo JSC,Ng KW. Exposure to titanium dioxide nanoparticles induces autophagy in primary human keratinocytes. Small 9, 387-392, (2013) [https://doi.org/10.1002/smll.201201363].
  18. Zhao X, Ong KJ, Ede JD, Stafford JL, Ng KW, Goss GG,Loo SCJ. Evaluating the toxicity of hydroxyapatite nanoparticles in catfish cells and zebrafish embryos. Small 9, 1734-1741, (2013) [https://doi.org/10.1002/smll.201200639].
  19. Zhao X, Ng S, Heng BC, Guo J, Ma L, Tan TTY, Ng KW,Loo SCJ. Cytotoxicity of hydroxyapatite nanoparticles is shape and cell dependent. Archives of Toxicology 87, 1037-1052, (2013) [https://doi.org/10.1007/s00204-012-0827-1].
  20. Yu H, Lui YS, Xiong S, Leong WS, Wen F, Nurkahfianto H, Rana S, Leong DT, Ng KW,Tan LP. Insights into the role of focal adhesion modulation in myogenic differentiation of human mesenchymal stem cells. Stem Cells and Development 22, 136-147, (2013) [https://doi.org/10.1089/scd.2012.0160].
  21. Xiong S, Tang Y, Ng HS, Zhao X, Jiang Z, Chen Z, Ng KW,Loo SCJ. Specific surface area of titanium dioxide (TiO2) particles influences cyto- and photo-toxicity. Toxicology 304, 132-140, (2013) [https://doi.org/10.1016/j.tox.2012.12.015].
  22. Xiong S, George S, Yu H, Damoiseaux R, France B, Ng KW,Loo JSC. Size influences the cytotoxicity of poly (lactic-co-glycolic acid) (PLGA) and titanium dioxide (TiO2) nanoparticles. Archives of Toxicology 87, 1075-1086, (2013) [https://doi.org/10.1007/s00204-012-0938-8].
  23. Xiong S, George S, Ji Z, Lin S, Yu H, Damoiseaux R, France B, Ng KW,Loo SCJ. Size of TiO2 nanoparticles influences their phototoxicity: An in vitro investigation. Archives of Toxicology 87, 99-109, (2013) [https://doi.org/10.1007/s00204-012-0912-5].
  24. Wu YL, Putcha N, Ng KW, Leong DT, Lim CT, Loo SCJ,Chen X. Biophysical responses upon the interaction of nanomaterials with cellular interfaces. Accounts of Chemical Research 46, 782-791, (2013) [https://doi.org/10.1021/ar300046u].
  25. Tay CY, Fang W, Setyawati MI, Sum CP, Xie J, Ng KW, Chen X, Hong CHL,Leong DT. Reciprocal response of human oral epithelial cells to internalized silica nanoparticles. Particle and Particle Systems Characterization 30, 784-793, (2013) [https://doi.org/10.1002/ppsc.201300111].
  26. Sow WT, Lui YS,Ng KW. Electrospun human keratin matrices as templates for tissue regeneration. Nanomedicine 8, 531-541, (2013) [https://doi.org/10.2217/nnm.13.38].
  27. Setyawati MI, Tay CY, Chia SL, Goh SL, Fang W, Neo MJ, Chong HC, Tan SM, Loo SCJ, Ng KW, Xie JP, Ong CN, Tan NS,Leong DT. Titanium dioxide nanomaterials cause endothelial cell leakiness by disrupting the homophilic interaction of VE-cadherin. Nature Communications 4, (2013) [https://doi.org/10.1038/ncomms2655].
  28. Setyawati MI, Khoo PKS, Eng BH, Xiong S, Zhao X, Das GK, Tan TTY, Loo JSC, Leong DT,Ng KW. Cytotoxic and genotoxic characterization of titanium dioxide, gadolinium oxide, and poly(lactic-co-glycolic acid) nanoparticles in human fibroblasts. Journal of Biomedical Materials Research – Part A 101 A, 633-640, (2013) [https://doi.org/10.1002/jbm.a.34363].
  29. Ma X, Zhao Y, Ng KW,Zhao Y. Integrated hollow mesoporous silica nanoparticles for target drug/siRNA co-delivery. Chemistry – A European Journal 19, 15593-15603, (2013) [https://doi.org/10.1002/chem.201302736].
  30. Low YKA, Tan LY, Tan LP, Boey FYC,Ng KW. Increasing solvent polarity and addition of salts promote β-phase poly(vinylidene fluoride) formation. Journal of Applied Polymer Science 128, 2902-2910, (2013) [https://doi.org/10.1002/app.38451].
  31. Li H, Wong YS, Wen F, Ng KW, Ng GKL, Venkatraman SS, Boey FYC,Tan LP. Human Mesenchymal Stem-Cell Behaviour On Direct Laser Micropatterned Electrospun Scaffolds with Hierarchical Structures. Macromolecular Bioscience 13, 299-310, (2013) [https://doi.org/10.1002/mabi.201200318].
  32. Kathawala MH, Xiong S, Richards M, Ng KW, George S,Loo SCJ. Emerging in vitro models for safety screening of high-volume production nanomaterials under environmentally relevant exposure conditions. Small 9, 1504-1520, (2013) [https://doi.org/10.1002/smll.201201452].
  33. Ho VHB, Guo WM, Huang CL, Ho SF, Chaw SY, Tan EY, Ng KW,Loo JSC. Manipulating magnetic 3D spheroids in hanging drops for applications in tissue engineering and drug screening. Advanced Healthcare Materials 2, 1430-1434, (2013) [https://doi.org/10.1002/adhm.201200408].
  34. Wang S, Taraballi F, Tan LP,Ng KW. Human keratin hydrogels support fibroblast attachment and proliferation in vitro. Cell and Tissue Research 347, 795-802, (2012) [https://doi.org/10.1007/s00441-011-1295-2].
  35. Taraballi F, Wang S, Li J, Lee FYY, Venkatraman SS, Birch WR, Teoh SH, Boey FYC,Ng KW. Understanding the nano-topography changes and cellular influences resulting from the surface adsorption of human hair keratins. Advanced Healthcare Materials 1, 513-519, (2012) [https://doi.org/10.1002/adhm.201200043].
  36. Li H, Wen F, Wong YS, Boey FYC, Subbu VS, Leong DT, Ng KW, Ng GKL,Tan LP. Direct laser machining-induced topographic pattern promotes up-regulation of myogenic markers in human mesenchymal stem cells. Acta Biomaterialia 8, 531-539, (2012) [https://doi.org/10.1016/j.actbio.2011.09.029].
  37. Zhao X, Heng BC, Xiong S, Guo J, Tan TTY, Boey FYC, Ng KW,Loo JSC. In vitro assessment of cellular responses to rod-shaped hydroxyapatite nanoparticles of varying lengths and surface areas. Nanotoxicology 5, 182-194, (2011) [https://doi.org/10.3109/17435390.2010.503943].
  38. Xiong S, Zhao X, Heng BC, Ng KW,Loo JSC. Cellular uptake of Poly-(D,L-lactide-co-glycolide) (PLGA) nanoparticles synthesized through solvent emulsion evaporation and nanoprecipitation method. Biotechnology Journal 6, 501-508, (2011) [https://doi.org/10.1002/biot.201000351].
  39. Tay CY, Pal M, Yu H, Leong WS, Tan NS, Ng KW, Venkatraman S, Boey F, Leong DT,Tan LP. Bio-inspired micropatterned platform to steer stem cell differentiation. Small 7, 1416-1421, (2011) [https://doi.org/10.1002/smll.201002298].
  40. Ng KW, Khoo SPK, Heng BC, Setyawati MI, Tan EC, Zhao X, Xiong S, Fang W, Leong DT,Loo JSC. The role of the tumor suppressor p53 pathway in the cellular DNA damage response to zinc oxide nanoparticles. Biomaterials 32, 8218-8225, (2011) [https://doi.org/10.1016/j.biomaterials.2011.07.036].
  41. Ng KW, Abraham MC, Leong DTW, Morris C,Schantz J. Primary Culture of Specific Cell Types and the Establishment of Cell Lines. Animal Cell Culture: Essential Methods https://doi.org/10.1002/9780470669815.ch7, 205-230, (2011) [https://doi.org/10.1002/9780470669815.ch7].
  42. Menéndez S, Goh AM, Camus S, Ng KW, Kua N, Badal V,Lane DP. MDM4 downregulates p53 transcriptional activity and response to stress during differentiation. Cell Cycle 10, 1100-1108, (2011) [https://doi.org/10.4161/cc.10.7.15090].
  43. Low YKA, Meenubharathi N, Niphadkar ND, Boey FYC,Ng KW. α- and β-poly (vinylidene fluoride) evoke different cellular behaviours. Journal of Biomaterials Science, Polymer Edition 22, 1651-1667, (2011) [https://doi.org/10.1163/092050610X519471].
  44. Heng BC, Zhao X, Xiong S, Ng KW, Boey FYC,Loo JSC. Cytotoxicity of zinc oxide (ZnO) nanoparticles is influenced by cell density and culture format. Archives of Toxicology 85, 695-704, (2011) [https://doi.org/10.1007/s00204-010-0608-7].
  45. Heng BC, Zhao X, Tan EC, Khamis N, Assodani A, Xiong S, Ruedl C, Ng KW,Loo JSC. Evaluation of the cytotoxic and inflammatory potential of differentially shaped zinc oxide nanoparticles. Archives of Toxicology 85, 1517-1528, (2011) [https://doi.org/10.1007/s00204-011-0722-1].

Publications

Year 2016 – 2020

  1. Zhao Z, Vizetto-Duarte C, Moay ZK, Setyawati MI, Rakshit M, Kathawala MH,Ng KW. Composite Hydrogels in Three-Dimensional in vitro Models. Frontiers in Bioengineering and Biotechnology 8, 611, (2020) [https://doi.org/10.3389/fbioe.2020.00611].
  2. Yang Q, Keerthisinghe TP, Tan TRJ, Cao X, Setyawati MI, Deloid G, Ng KW, Loo SCJ, Demokritou P,Fang M. A high-throughput method to characterize the gut bacteria growth upon engineered nanomaterial treatment. Environmental Science: Nano 7, 3155-3166, (2020) [https://doi.org/10.1039/d0en00568a].
  3. Xu T, Ma C, Aytac Z, Hu X, Ng KW, White JC,Demokritou P. Enhancing Agrichemical Delivery and Seedling Development with Biodegradable, Tunable, Biopolymer-Based Nanofiber Seed Coatings. ACS Sustainable Chemistry and Engineering 8, 9537-9548, (2020) [https://doi.org/10.1021/acssuschemeng.0c02696].
  4. Wu Z, Shi P, Lim HK, Ma Y, Setyawati MI, Bitounis D, Demokritou P, Ng KW,Tay CY. Inflammation Increases Susceptibility of Human Small Airway Epithelial Cells to Pneumonic Nanotoxicity. Small 16, 2000963, (2020) [https://doi.org/10.1002/smll.202000963].
  5. Wu Z, Lim HK, Tan SJ, Gautam A, Hou HW, Ng KW, Tan NS,Tay CY. Potent-By-Design: Amino Acids Mimicking Porous Nanotherapeutics with Intrinsic Anticancer Targeting Properties. Small 16, 2003757, (2020) [https://doi.org/10.1002/smll.202003757].
  6. Setyawati MI, Zhao Z,Ng KW. Transformation of Nanomaterials and Its Implications in Gut Nanotoxicology. Small 16, 2001246, (2020) [https://doi.org/10.1002/smll.202001246].
  7. Setyawati MI, Singh D, Krishnan SPR, Huang X, Wang M, Jia S, Goh BHR, Ho CG, Yusoff R, Kathawala MH, Poh TY, Ali NABM, Chotirmall SH, Aitken RJ, Riediker M, Christiani DC, Fang M, Bello D, Demokritou P,Ng KW. Occupational Inhalation Exposures to Nanoparticles at Six Singapore Printing Centers. Environmental Science and Technology 54, 2389-2400, (2020) [https://doi.org/10.1021/acs.est.9b06984].
  8. Rakshit M, Gautam A, Toh LZ, Lee YS, Lai HY, Wong TT,Ng KW. Hydroxyapatite particles induced modulation of collagen expression and secretion in primary human dermal fibroblasts. International Journal of Nanomedicine 15, 4943-4956, (2020) [https://doi.org/10.2147/IJN.S245500].
  9. Khanal D, Lei Q, Pinget G, Cheong DA, Gautam A, Yusoff R, Su B, Yamaguchi S, Kondyurin A, Knowles JC, Georgiou G, Macia L, Jang JH, Ramzan I, Ng KW,Chrzanowski W. The protein corona determines the cytotoxicity of nanodiamonds: implications of corona formation and its remodelling on nanodiamond applications in biomedical imaging and drug delivery. Nanoscale Advances 2, 4798-4812, (2020) [https://doi.org/10.1039/d0na00231c].
  10. Hedegaard CL, Redondo-Gómez C, Tan BY, Ng KW, Loessner D,Mata A. Peptide-protein coassembling matrices as a biomimetic 3d model of ovarian cancer. Science Advances 6, eabb3298, (2020) [https://doi.org/10.1126/sciadv.abb3298].
  11. Guo Z, Cao X, Deloid GM, Sampathkumar K, Ng KW, Loo SCJ,Demokritou P. Physicochemical and Morphological Transformations of Chitosan Nanoparticles across the Gastrointestinal Tract and Cellular Toxicity in an in Vitro Model of the Small Intestinal Epithelium. Journal of Agricultural and Food Chemistry 68, 358-368, (2020) [https://doi.org/10.1021/acs.jafc.9b05506].
  12. Guo NL, Bello D, Ye Q, Tagett R, Chanetsa L, Singh D, Poh TY, Setyawati MI, Chotirmall SH, Ng KW,Demokritou P. Pilot deep RNA sequencing of worker blood samples from Singapore printing industry for occupational risk assessment. NanoImpact 19, 100248, (2020) [https://doi.org/10.1016/j.impact.2020.100248].
  13. Darwitan A, Wong YS, Nguyen LTH, Czarny B, Vincent A, Nedumaran AM, Tan YF, Muktabar A, Tang JK, Ng KW,Venkatraman S. Liposomal Nanotherapy for Treatment of Atherosclerosis. Advanced Healthcare Materials 9, 2000465, (2020) [https://doi.org/10.1002/adhm.202000465].
  14. Chua HM, Zhao Z,Ng KW. Cryogelation of Human Hair Keratins. Macromolecular Rapid Communications 41, 2000254, (2020) [https://doi.org/10.1002/marc.202000254].
  15. Aytac Z, Huang R, Vaze N, Xu T, Eitzer BD, Krol W, MacQueen LA, Chang H, Bousfield DW, Chan-Park MB, Ng KW, Parker KK, White JC,Demokritou P. Development of Biodegradable and Antimicrobial Electrospun Zein Fibers for Food Packaging. ACS Sustainable Chemistry and Engineering 8, 15354-15365, (2020) [https://doi.org/10.1021/acssuschemeng.0c05917].
  16. Tan S, Yu CY, Sim ZW, Low ZS, Lee B, See F, Min N, Gautam A, Chu JJH, Ng KW,Wong E. Pomegranate activates TFEB to promote autophagy-lysosomal fitness and mitophagy. Scientific Reports 9, 1-18, (2019) [https://doi.org/10.1038/s41598-018-37400-1].
  17. Khanal D, Zhang F, Song Y, Hau H, Gautam A, Yamaguchi S, Uertz J, Mills S, Kondyurin A, Knowles JC, Georgiou G, Ramzan I, Cai W, Ng KW,Chrzanowski W. Biological impact of nanodiamond particles–label free, high-resolution methods for nanotoxicity assessment. Nanotoxicology 13, 1210-1226, (2019) [https://doi.org/10.1080/17435390.2019.1650970].
  18. Kathawala MH, Ng WL, Liu D, Naing MW, Yeong WY, Spiller KL, Van Dyke M,Ng KW. Healing of Chronic Wounds: An Update of Recent Developments and Future Possibilities. Tissue Engineering – Part B: Reviews 25, 429-444, (2019) [https://doi.org/10.1089/ten.teb.2019.0019].
  19. Guo NL, Poh TY, Pirela S, Farcas MT, Chotirmall SH, Tham WK, Adav SS, Ye Q, Wei Y, Shen S, Christiani DC, Ng KW, Thomas T, Qian Y,Demokritou P. Integrated transcriptomics, metabolomics, and lipidomics profiling in rat lung, blood, and serum for assessment of laser printer-emitted nanoparticle inhalation exposure-induced disease risks. International Journal of Molecular Sciences 20, 6348, (2019) [https://doi.org/10.3390/ijms20246348].
  20. Goh WL, Luo B, Zeng Z, Yuan J,Ng KW. Effects of hardness and toughness of ceramic in a ceramic armour module against long rod impacts C3 – Ceramic Engineering and Science Proceedings.  39, 187-198, (2019)
  21. Gautam A, Rakshit M, Nguyen KT, Kathawala MH, Nguyen LTH, Tay CY, Wong E,Ng KW. Understanding the implications of engineered nanoparticle induced autophagy in human epidermal keratinocytes in vitro. NanoImpact 15, 100177, (2019) [https://doi.org/10.1016/j.impact.2019.100177].
  22. Deloid GM, Cao X, Molina RM, Silva DI, Bhattacharya K, Ng KW, Loo SCJ, Brain JD,Demokritou P. Toxicological effects of ingested nanocellulose in: In vitro intestinal epithelium and in vivo rat models. Environmental Science: Nano 6, 2105-2115, (2019) [https://doi.org/10.1039/c9en00184k].
  23. Carvalho CR, Costa JB, Costa L, Silva-Correia J, Moay ZK, Ng KW, Reis RL,Oliveira JM. Enhanced performance of chitosan/keratin membranes with potential application in peripheral nerve repair. Biomaterials Science 7, 5451-5466, (2019) [https://doi.org/10.1039/c9bm01098j].
  24. Cao X, Deloid GM, Bitounis D, De La Torre-Roche R, White JC, Zhang Z, Ho CG, Ng KW, Eitzer BD,Demokritou P. Co-exposure to the food additives SiO2 (E551) or TiO2 (E171) and the pesticide boscalid increases cytotoxicity and bioavailability of the pesticide in a tri-culture small intestinal epithelium model: Potential health implications. Environmental Science: Nano 6, 2786-2800, (2019) [https://doi.org/10.1039/c9en00676a].
  25. Yusoff R, Nguyen LTH, Chiew P, Wang ZM,Ng KW. Comparative differences in the behavior of TiO2 and SiO2 food additives in food ingredient solutions. Journal of Nanoparticle Research 20, 1-13, (2018) [https://doi.org/10.1007/s11051-018-4176-8].
  26. Yusoff R, Kathawala MH, Nguyen LTH, Setyawati MI, Chiew P, Wu Y, Ch’ng AL, Wang ZM,Ng KW. Biomolecular interaction and kinematics differences between P25 and E171 TiO2 nanoparticles. NanoImpact 12, 51-57, (2018) [https://doi.org/10.1016/j.impact.2018.10.001].
  27. Wu Z, Yang H, Archana G, Rakshit M, Ng KW,Tay CY. Human keratinocytes adapt to ZnO nanoparticles induced toxicity via complex paracrine crosstalk and Nrf2-proteasomal signal transduction. Nanotoxicology 12, 1215-1229, (2018) [https://doi.org/10.1080/17435390.2018.1537409].
  28. Tan YF, Lee YS, Seet LF, Ng KW, Wong TT,Venkatraman S. Design and in vitro release study of siRNA loaded Layer by Layer nanoparticles with sustained gene silencing effect. Expert Opinion on Drug Delivery 15, 937-949, (2018) [https://doi.org/10.1080/17425247.2018.1518426].
  29. Subbaiah RS, Kerk SK, Lian Y, Lunny D, Sze SK, Ng KW, Schmidtchen A,Adav SS. Identification of antibacterial components in human hair shafts. Acta Dermato-Venereologica 98, 708-710, (2018) [https://doi.org/10.2340/00015555-2952].
  30. Sevivas N, Teixeira FG, Portugal R, Direito-Santos B, Espregueira-Mendes J, Oliveira FJ, Silva RF, Sousa N, Sow WT, Nguyen LTH, Ng KW,Salgado AJ. Mesenchymal Stem Cell Secretome Improves Tendon Cell Viability In Vitro and Tendon-Bone Healing In Vivo When a Tissue Engineering Strategy Is Used in a Rat Model of Chronic Massive Rotator Cuff Tear. American Journal of Sports Medicine 46, 449-459, (2018) [https://doi.org/10.1177/0363546517735850].
  31. Poh TY, Ali NABM, Mac Aogáin M, Kathawala MH, Setyawati MI, Ng KW,Chotirmall SH. Inhaled nanomaterials and the respiratory microbiome: Clinical, immunological and toxicological perspectives. Particle and Fibre Toxicology 15, 1-16, (2018) [https://doi.org/10.1186/s12989-018-0282-0].
  32. Nguyen LTH, Muktabar A, Tang J, Wong YS, Thaxton CS, Venkatraman SS,Ng KW. The Potential of Fluocinolone Acetonide to Mitigate Inflammation and Lipid Accumulation in 2D and 3D Foam Cell Cultures. BioMed Research International 2018, (2018) [https://doi.org/10.1155/2018/3739251].
  33. Lai HY, Wang S, Singh V, Nguyen LTH,Ng KW. Evaluating the antioxidant effects of human hair protein extracts. Journal of Biomaterials Science, Polymer Edition 29, 1081-1093, (2018) [https://doi.org/10.1080/09205063.2017.1421345].
  34. Kerk SK, Lai HY, Sze SK, Ng KW, Schmidtchen A,Adav SS. Bacteria display differential growth and adhesion characteristics on human hair shafts. Frontiers in Microbiology 9, (2018) [https://doi.org/10.3389/fmicb.2018.02145].
  35. Hedegaard CL, Collin EC, Redondo-Gómez C, Nguyen LTH, Ng KW, Castrejón-Pita AA, Castrejón-Pita JR,Mata A. Hydrodynamically Guided Hierarchical Self-Assembly of Peptide–Protein Bioinks. Advanced Functional Materials 28, 1703716, (2018) [https://doi.org/10.1002/adfm.201703716].
  36. Deloid GM, Sohal IS, Lorente LR, Molina RM, Pyrgiotakis G, Stevanovic A, Zhang R, McClements DJ, Geitner NK, Bousfield DW, Ng KW, Loo SCJ, Bell DC, Brain J,Demokritou P. Reducing Intestinal Digestion and Absorption of Fat Using a Nature-Derived Biopolymer: Interference of Triglyceride Hydrolysis by Nanocellulose. ACS Nano 12, 6469-6479, (2018) [https://doi.org/10.1021/acsnano.8b03074].
  37. Adav SS, Subbaiaih RS, Kerk SK, Lee AY, Lai HY, Ng KW, Sze SK,Schmidtchen A. Studies on the Proteome of Human Hair – Identification of Histones and Deamidated Keratins. Scientific Reports 8, 1-11, (2018) [https://doi.org/10.1038/s41598-018-20041-9].
  38. Tan BY, Nguyen LTH, Kim HS, Kim JH,Ng KW. Cultivation of human dermal fibroblasts and epidermal keratinocytes on keratin-coated silica bead substrates. Journal of Biomedical Materials Research – Part A 105, 2789-2798, (2017) [https://doi.org/10.1002/jbm.a.36142].
  39. Singh V, Wang S,Ng KW. 2.25 Keratin as a biomaterial. Comprehensive Biomaterials II https://doi.org/10.1016/B978-0-12-803581-8.09317-6, 542-557, (2017) [https://doi.org/10.1016/B978-0-12-803581-8.09317-6].
  40. Sevivas N, França G, Oliveira N, Pereira H, Ng KW, Salgado A,Espregueira-Mendes J. Biomaterials for tendon regeneration. Muscle and Tendon Injuries: Evaluation and Management https://doi.org/10.1007/978-3-662-54184-5_13, 131-143, (2017) [https://doi.org/10.1007/978-3-662-54184-5_13].
  41. Nguyen LTH, Muktabar A, Tang J, Dravid VP, Thaxton CS, Venkatraman S,Ng KW. Engineered nanoparticles for the detection, treatment and prevention of atherosclerosis: how close are we? Drug Discovery Today 22, 1438-1446, (2017) [https://doi.org/10.1016/j.drudis.2017.07.006].
  42. Ko J, Nguyen LTH, Surendran A, Tan BY, Ng KW,Leong WL. Human Hair Keratin for Biocompatible Flexible and Transient Electronic Devices. ACS Applied Materials and Interfaces 9, 43004-43012, (2017) [https://doi.org/10.1021/acsami.7b16330].
  43. Hartrianti P, Nguyen LTH, Johanes J, Chou SM, Zhu P, Tan NS, Tang MBY,Ng KW. Fabrication and characterization of a novel crosslinked human keratin-alginate sponge. Journal of Tissue Engineering and Regenerative Medicine 11, 2590-2602, (2017) [https://doi.org/10.1002/term.2159].
  44.  Goh WL, Zheng Y, Yuan J,Ng KW. Effects of hardness of steel on ceramic armour module against long rod impact. International Journal of Impact Engineering 109, 419-426, (2017) [https://doi.org/10.1016/j.ijimpeng.2017.08.004].
  45. Zhao X, Lang Q, Yildirimer L, Lin ZY, Cui W, Annabi N, Ng KW, Dokmeci MR, Ghaemmaghami AM,Khademhosseini A. Photocrosslinkable Gelatin Hydrogel for Epidermal Tissue Engineering. Advanced Healthcare Materials 5, 108-118, (2016) [https://doi.org/10.1002/adhm.201500005].
  46. Leong WS, Wu SC, Ng KW,Tan LP. Electrospun 3D multi-scale fibrous scaffold for enhanced human dermal fibroblasts infiltration. International Journal of Bioprinting 2, 81-92, (2016) [https://doi.org/10.18063/IJB.2016.01.002]

Publications

Year 2021

  1. Zhao Z, Moay ZK, Lai HY, Goh BHR, Chua HM, Setyawati MI,Ng KW. Characterization of Anisotropic Human Hair Keratin Scaffolds Fabricated via Directed Ice Templating. Macromolecular Bioscience 21, 2000314, (2021) [https://doi.org/10.1002/mabi.202000314].
  2. Zhang N, Lai HY, Gautam A, De Kwek DY, Dong Y, Wang Q,Ng KW. An Enzymatic Method for Harvesting Functional Melanosomes after Keratin Extraction: Maximizing Resource Recovery from Human Hair. Journal of Polymers and the Environment 13, 50298-50308, (2021) [https://doi.org/10.1007/s10924-021-02246-8].
  3. Zhang N, Lai H, Gautam A, Zhao Z, Wang Q,Ng KW. Facile and Efficient Enzymatic Methods for Harvesting or Removal of Cuticle Cells from Human Hair Shafts. Journal of Natural Fibers https://doi.org/10.1080/15440478.2021.2009397, 1-14, (2021) [https://doi.org/10.1080/15440478.2021.2009397].
  4. Toprani SM, Bitounis D, Huang Q, Oliveira N, Ng KW, Tay CY, Nagel ZD,Demokritou P. High-Throughput Screening Platform for Nanoparticle-Mediated Alterations of DNA Repair Capacity. ACS Nano 15, 4728-4746, (2021) [https://doi.org/10.1021/acsnano.0c09254].
  5. Tang J, Rakshit M, Chua HM, Darwitan A, Nguyen LTH, Muktabar A, Venkatraman S,Ng KW. Liposome interaction with macrophages and foam cells for atherosclerosis treatment: Effects of size, surface charge and lipid composition. Nanotechnology 32, 505105, (2021) [https://doi.org/10.1088/1361-6528/ac2810].
  6. Suryani L, Foo JKR, Cardilla A, Dong Y, Muthukumaran P, Hassanbhai A, Wen F, Simon DT, Iandolo D, Yu N, Ng KW,Teoh SH. Effects of pulsed electromagnetic field intensity on mesenchymal stem cells. Bioelectricity 3, 186-196, (2021) [https://doi.org/10.1089/bioe.2021.0002].
  7. Su X, Rakshit M, Das P, Gupta I, Das D, Pramanik M, Ng KW,Kwan J. Ultrasonic Implantation and Imaging of Sound-Sensitive Theranostic Agents for the Treatment of Arterial Inflammation. ACS Applied Materials and Interfaces 13, 24422–24430, (2021) [https://doi.org/10.1021/acsami.1c01161].
  8. Rakshit M, Darwitan A, Muktabar A, Das P, Nguyen LTH, Cao Y, Vizetto-Duarte C, Tang J, Wong YS, Venkatraman S,Ng KW. Anti-inflammatory potential of simvastatin loaded nanoliposomes in 2D and 3D foam cell models. Nanomedicine: Nanotechnology, Biology, and Medicine 37, 102434, (2021) [https://doi.org/10.1016/j.nano.2021.102434].
  9. Moay ZK, Nguyen LTH, Hartrianti P, Lunny DP, Leavesley D, Kok YO, Chong SJ, Chua AWC, Tee SI,Ng KW. Keratin‐alginate sponges support healing of partial‐thickness burns. International Journal of Molecular Sciences 22, 8594, (2021) [https://doi.org/10.3390/ijms22168594].
  10. Lai HY, Setyawati MI, Ferhan AR, Divakarla SK, Chua HM, Cho NJ, Chrzanowski W,Ng KW. Self-Assembly of Solubilized Human Hair Keratins. ACS Biomaterials Science and Engineering 7, 83-89, (2021) [https://doi.org/10.1021/acsbiomaterials.0c01507].
  11. Khin MM, Bao Y, Liang YN, Setyawati MI, Gnayem H, Ng KW, Sasson Y,Hu X. BiOClBr-coated fabrics with enhanced antimicrobial properties under ambient light. Journal of Materials Chemistry B 9, 3079-3087, (2021) [https://doi.org/10.1039/d0tb02835e].
  12. Guo Z, DeLoid GM, Cao X, Bitounis D, Sampathkumar K, Ng KW, Loo SCJ,Demokritou P. Effects of ingested nanocellulose and nanochitosan materials on carbohydrate digestion and absorption in anin vitrosmall intestinal epithelium model. Environmental Science: Nano 8, 2554-2568, (2021) [https://doi.org/10.1039/d1en00233c].
  13. Gentile P, De Giglio E, Hilborn JG,Ng KW. Editorial: Composite and Functionalized Hydrogels: Implications for Improved and Biological Properties in Tissue Engineering. Frontiers in Bioengineering and Biotechnology 8, 1524, (2021) [https://doi.org/10.3389/fbioe.2020.636575].
  14. Dong Y, Suryani L, Zhou X, Muthukumaran P, Rakshit M, Yang F, Wen F, Hassanbhai AM, Parida K, Simon DT, Iandolo D, Lee PS, Ng KW,Teoh SH. Synergistic effect of pvdf-coated pcl-tcp scaffolds and pulsed electromagnetic field on osteogenesis. International Journal of Molecular Sciences 22, 6438, (2021) [https://doi.org/10.3390/ijms22126438].
  15. Cao X, Pan X, Couvillion SP, Zhang T, Tamez C, Bramer LM, White JC, Qian WJ, Thrall BD, Ng KW, Hu X,Demokritou P. Fate, cytotoxicity and cellular metabolomic impact of ingested nanoscale carbon dots using simulated digestion and a triculture small intestinal epithelial model. NanoImpact 23, 100349, (2021) [https://doi.org/10.1016/j.impact.2021.100349].
  16. Bello D, Chanetsa L, Cristophi CA, Poh TY, Singh D, Setyawati MI, Christiani D, Chotirmall SH, Ng KW,Demokritou P. Chronic upper airway and systemic inflammation from copier emitted particles in healthy operators at six Singaporean workplaces. NanoImpact 22, 100325, (2021) [https://doi.org/10.1016/j.impact.2021.100325].
  17. Aytac Z, Xu J, Raman Pillai SK, Eitzer BD, Xu T, Vaze N, Ng KW, White JC, Chan-Park MB, Luo Y,Demokritou P. Enzyme- And Relative Humidity-Responsive Antimicrobial Fibers for Active Food Packaging. ACS Applied Materials and Interfaces 13, 50298-50308, (2021) [https://doi.org/10.1021/acsami.1c12319]

Publication

Year 2022

  1. Zhao Z, Xu T, Pan X, Susanti, White JC, Hu X, Miao Y, Demokritou P,Ng KW. Sustainable Nutrient Substrates for Enhanced Seedling Development in Hydroponics. ACS Sustainable Chemistry & Engineering 10, 8506-8516, (2022) [https://doi.org/10.1021/acssuschemeng.2c01668].
  2. Zhao Z, Chua HM, Goh BHR, Lai HY, Tan SJ, Moay ZK, Setyawati MI,Ng KW. Anisotropic hair keratin-dopamine composite scaffolds exhibit strain-stiffening properties. Journal of Biomedical Materials Research – Part A 110, 92-104, (2022) [https://doi.org/10.1002/jbm.a.37268].
  3. Tan BY, Nguyen LTH,Ng KW. Development of a mechanically stable human hair keratin film for cell culture. Materials Today Communications 30, 103049, (2022) [https://doi.org/10.1016/j.mtcomm.2021.103049].
  4. Lim HK, Hughes CO, Lim MJS, Li JEJ, Rakshit M, Yeo C, Chng KR, Li A, Chan JSH, Ng KW, Leavesley DI,Smith BPC. Development of reconstructed intestinal micronucleus cytome (RICyt) assay in 3D human gut model for genotoxicity assessment of orally ingested substances. Archives of Toxicology https://doi.org/10.1007/s00204-022-03228-y, (2022) [https://doi.org/10.1007/s00204-022-03228-y].
  5. Jia S, Setyawati MI, Liu M, Xu T, Loo J, Yan M, Gong J, Chotirmall SH, Demokritou P, Ng KW,Fang M. Association of nanoparticle exposure with serum metabolic disorders of healthy adults in printing centers. Journal of Hazardous Materials 432, 128710, (2022) [https://doi.org/10.1016/j.jhazmat.2022.128710].
  6. Bitounis D, Huang Q, Toprani SM, Setyawati MI, Oliveira N, Wu Z, Tay CY, Ng KW, Nagel ZD,Demokritou P. Printer center nanoparticles alter the DNA repair capacity of human bronchial airway epithelial cells. NanoImpact 25, 100379, (2022)