The hyrophobic (water resistant ) and lipophylic (ability to dissolve in fat-like solvent) characteristic of -CF3 group are important to aid in transportation of therapeutic drug to the active site in the body. Moreover, drug’s stability properties is improved due to strong carbon-fluorine bond.“These factors are crucial for the development of therapeutic drugs and agrochemicals,” says Sodeoka (Efficient and versatile chemistry (2012, Oct 05). Retrieved from http://www.rikenresearch.riken.jp/eng/research/7036.html)
Mikiko Sodeoka and her colleagues at the RIKEN Advanced Science Institute in Wako has successfuly develop an efficient reaction to insert the -CF3 group into organic molecule through the formation of allylsilane, another functional group comprised of silicone, using copper catalyst.
Original research paper was published at Angewandte Chemie International Edition 51, 4577–4580 (2012) . Full article is available from NTU library (for NTU staffs and students) at :