Tag Archives: drug delivery

Hot-melt extrusion : pharmaceutical applications

Title: Hot-melt extrusion : pharmaceutical applications
Author:  Douroumis, Dionysios
Call number: TP156.M65H832
Availability:  Click here

Hot-melt extrusion is an emerging continuous processing technology for developing various solid dosage forms and drug delivery systems that has attract increasing attention in both academic and commercial settings for the past 20 years. Here chemists review the theory, instrumentation, and wide spectrum of applications. Among their topics are principles of single-screw extrusion, solubility parameters for predicting drug/polymer miscibility in hot-melt extruded formulations, taste masking using hot-melt extrusion, laminar dispersive and distributive mixing with dissolution and applications to hot-melt extrusion, and devices and implant systems by hot-melt extrusion. Annotation ©2012 Book News, Inc., Portland, OR (booknews.com)
[As taken from Syndetics]

Fluorine in organic molecule

The hyrophobic (water resistant ) and lipophylic (ability to dissolve in fat-like solvent) characteristic of -CF3 group are important to aid in transportation of therapeutic drug to the active site in the body. Moreover, drug’s stability properties is improved due to strong carbon-fluorine bond.“These factors are crucial for the development of therapeutic drugs and agrochemicals,” says Sodeoka  (Efficient and versatile chemistry (2012, Oct 05). Retrieved from http://www.rikenresearch.riken.jp/eng/research/7036.html)

Mikiko Sodeoka and her colleagues at the RIKEN Advanced Science Institute in Wako has successfuly develop an efficient  reaction to insert the -CF3 group into organic molecule through the formation of allylsilane, another functional group comprised of silicone, using copper catalyst.

Image taken from http://www.rikenresearch.riken.jp/eng/research/7036.html

Original research paper was published at Angewandte Chemie International Edition 51, 4577–4580 (2012) . Full article is available from NTU library (for NTU staffs and students) at :




Leachables and extractables handbook : safety evaluation, qualification, and best practices applied to inhalation drug products

Title: Leachables and extractables handbook : safety evaluation, qualification, and best practices applied to inhalation drug products.
Author:  Ball, Douglas J.
Call number: RS200.L434
Availability:  Click here

A practical and science-based approach for addressing toxicological concerns related to leachables and extractables associated with inhalation drug products

Packaging and device components of Orally Inhaled and Nasal Drug Products (OINDP)-such as metered dose inhalers, dry powder inhalers, and nasal sprays-pose potential safety risks from leachables and extractables, chemicals that can be released or migrate from these components into the drug product. Addressing the concepts, background, historical use, and development of safety thresholds and their utility for qualifying leachables and extractables in OINDP, the Leachables and Extractables Handbook takes a practical approach to familiarize readers with the recent recommendations for safety and risk assessment established through a joint effort of scientists from the FDA, academia, and industry. Coverage includes best practices for the chemical evaluation and management of leachables and extractables throughout the pharmaceutical product life cycle, as well as:

Guidance for pharmaceutical professionals to qualify and risk-assess container closure system leachables and extractables in drug products

Principles for defining toxicological safety thresholds that are applicable to OINDP and potentially applicable to other drug products

Regulatory perspectives, along with an appendix of key terms and definitions, case studies, and sample protocols

Analytical chemists, packaging and device engineers, formulation development scientists, component suppliers, regulatory affairs specialists, and toxicologists will all benefit from the wealth of information offered in this important text.
[As taken from Syndetics]