The hyrophobic (water resistant ) and lipophylic (ability to dissolve in fat-like solvent) characteristic of -CF3 group are important to aid in transportation of therapeutic drug to the active site in the body. Moreover, drug’s stability properties is improved due to strong carbon-fluorine bond.“These factors are crucial for the development of therapeutic drugs and agrochemicals,” says Sodeoka (Efficient and versatile chemistry (2012, Oct 05). Retrieved from http://www.rikenresearch.riken.jp/eng/research/7036.html)
Mikiko Sodeoka and her colleagues at the RIKEN Advanced Science Institute in Wako has successfuly develop an efficient reaction to insert the -CF3 group into organic molecule through the formation of allylsilane, another functional group comprised of silicone, using copper catalyst.
Image taken from http://www.rikenresearch.riken.jp/eng/research/7036.html
Original research paper was published at Angewandte Chemie International Edition 51, 4577–4580 (2012) . Full article is available from NTU library (for NTU staffs and students) at :
|Title: Collaborative computational technologies for biomedical research.
Author: Ekins, Sean.
Call number: RM301.25.C697
Availability: Click here
“The time has come to fundamentally rethink how we handle the building of knowledge in biomedical sciences today. This book describes how the computational sciences have transformed into being a key knowledge broker, able to integrate and operate across divergent data types.”—Bryn Williams-Jones, Associate Research Fellow, Pfizer
The pharmaceutical industry utilizes an extended network of partner organizations in order to discover and develop new drugs, however there is currently little guidance for managing information and resources across collaborations.
Featuring contributions from the leading experts in a range of industries, Collaborative Computational Technologies for Biomedical Research provides information that will help organizations make critical decisions about managing partnerships, including:
-Serving as a user manual for collaborations
-Tackling real problems from both human collaborative and data and informatics perspectives
-Providing case histories of biomedical collaborations and technology-specific chapters that balance technological depth with accessibility for the non-specialist reader
A must-read for anyone working in the pharmaceuticals industry or academia, this book marks a major step towards widespread collaboration facilitated by computational technologies.
[As taken from Amazon]