The hyrophobic (water resistant ) and lipophylic (ability to dissolve in fat-like solvent) characteristic of -CF3 group are important to aid in transportation of therapeutic drug to the active site in the body. Moreover, drug’s stability properties is improved due to strong carbon-fluorine bond.“These factors are crucial for the development of therapeutic drugs and agrochemicals,” says Sodeoka (Efficient and versatile chemistry (2012, Oct 05). Retrieved from http://www.rikenresearch.riken.jp/eng/research/7036.html)
Mikiko Sodeoka and her colleagues at the RIKEN Advanced Science Institute in Wako has successfuly develop an efficient reaction to insert the -CF3 group into organic molecule through the formation of allylsilane, another functional group comprised of silicone, using copper catalyst.
Image taken from http://www.rikenresearch.riken.jp/eng/research/7036.html
Original research paper was published at Angewandte Chemie International Edition 51, 4577–4580 (2012) . Full article is available from NTU library (for NTU staffs and students) at :
|Title: New strategies in chemical synthesis and catalysis.
Author: Pignataro, Bruno.
Call number: QD501.N532
Availability: Click here
Providing a comprehensive overview of the essential topics, this book covers the core areas of organic, inorganic, organometallic, biochemical synthesis and catalysis. The authors are among the rising stars in European chemistry, a selection of participants in the 2010 European Young Chemists Award competition, and their contributions deal with most of the frontier issues in chemical synthesis. They give an account of the latest research results in chemistry in Europe, as well as the state of the art in their field of research and the outlook for the future..
[As taken from Syndetics]
|Title: Practical process research and development : a guide for organic chemists, 2nd ed.
Author: Anderson, Neal G.
Call number: TP155.7.A548
Availability: Click here
Designed to provide a comprehensive, step-by-step approach to organic process research and development in the pharmaceutical, fine chemical, and agricultural chemical industries, this book describes the steps taken, following synthesis and evaluation, to bring key compounds to market in a cost-effective manner. It describes hands-on, step-by-step, approaches to solving process development problems, including route, reagent, and solvent selection; optimising catalytic reactions; chiral syntheses; and “green chemistry.”
Second Edition highlights: . Reflects the current thinking in chemical process R&D for small molecules . Retains similar structure and orientation to the first edition. . Contains approx. 85% new material . Primarily new examples (work-up and prospective considerations for pilot plant and manufacturing scale-up) . Some new/expanded topics (e.g. green chemistry, genotoxins, enzymatic processes) . Replaces the first edition, although the first edition contains useful older examples that readers may refer to.
[As taken from Amazon]