Tag Archives: Pharmaceutical chemistry

Fluorine in organic molecule

The hyrophobic (water resistant ) and lipophylic (ability to dissolve in fat-like solvent) characteristic of -CF3 group are important to aid in transportation of therapeutic drug to the active site in the body. Moreover, drug’s stability properties is improved due to strong carbon-fluorine bond.“These factors are crucial for the development of therapeutic drugs and agrochemicals,” says Sodeoka  (Efficient and versatile chemistry (2012, Oct 05). Retrieved from http://www.rikenresearch.riken.jp/eng/research/7036.html)

Mikiko Sodeoka and her colleagues at the RIKEN Advanced Science Institute in Wako has successfuly develop an efficient  reaction to insert the -CF3 group into organic molecule through the formation of allylsilane, another functional group comprised of silicone, using copper catalyst.

Image taken from http://www.rikenresearch.riken.jp/eng/research/7036.html

Original research paper was published at Angewandte Chemie International Edition 51, 4577–4580 (2012) . Full article is available from NTU library (for NTU staffs and students) at :

http://onlinelibrary.wiley.com.ezlibproxy1.ntu.edu.sg/doi/10.1002/anie.201201095/full

 

 

Practical process research and development : a guide for organic chemists 2nd ed.

Title: Practical process research and development : a guide for organic chemists, 2nd ed.
Author:  Anderson, Neal G.
Call number: TP155.7.A548
Availability:  Click here

Synopsis:
Designed to provide a comprehensive, step-by-step approach to organic process research and development in the pharmaceutical, fine chemical, and agricultural chemical industries, this book describes the steps taken, following synthesis and evaluation, to bring key compounds to market in a cost-effective manner. It describes hands-on, step-by-step, approaches to solving process development problems, including route, reagent, and solvent selection; optimising catalytic reactions; chiral syntheses; and “green chemistry.”

Second Edition highlights: . Reflects the current thinking in chemical process R&D for small molecules . Retains similar structure and orientation to the first edition. . Contains approx. 85% new material . Primarily new examples (work-up and prospective considerations for pilot plant and manufacturing scale-up) . Some new/expanded topics (e.g. green chemistry, genotoxins, enzymatic processes) . Replaces the first edition, although the first edition contains useful older examples that readers may refer to.

[As taken from Amazon]

New title for Chemical & Biomedical Engineering

Title:  Self-organized surfactant structures
Author:  Tadros, Th. F.
Call number: TP994.S465
Availability:  Click here

Synopsis:
Colloids play many versatile roles, as materials with particle sizes on the nanoscale displaying new or improved properties. They may have different colors depending on the current size, carry coatings with functions such as antigens for protein recognition, influence the morphology or durability of composites they are part of, serve as tiny containers for drugs, or as nanoreactors in which chemical reactions are conducted. Due to this diversity, colloidal chemistry involves a great number of disciplines, including chemistry, physics, materials sciences, and biology.

Highlighting recent developments as well as future challenges, this series of volumes covers such topics as emulsions, nano-emulsions, nano-dispersions and novel techniques for their investigation.

From the contents:
-Scientific Contributions by Professor Hironobu Kunieda
-Viscoelastic Worm-Like Micelles in Nonionic Fluorinated Surfactant Systems
-Structure of Nonionic Surfactant Micelles in Organic Solvents: A SAXS Study
-Nonionic Microemulsions: Dependence of Oil Chain Length and Active Component (Lidocaine)
-Some Characteristics of Lyotropic Liquid-Crystalline Mesophases
-Swelling of Vesicle Precipiates from Alkyldimethylaminoxide and Perfluoroalcohol by Refractive-Index Matching with Glycerol
-Si QDots: Where Does Photoluminescence Come From?
-Worm-Liek Micelles in a Binaery Solution of Nonionic Surfactant C16E7 and Water
-Mesophase Morphologies of Silicone Block Copolymers in a Selective Solvent Studied by SAXS
-Molecular Dynamics Study of Isoprenoid-Chained Lipids: Salient Features of Isoprenoid Chains As Compared
with Ordinary Alkyl Chains
-Structures of Poly(dimethylsiloxane)-Poly(oxythylene) Diblock Copolymer Micelles in Aqueous Solvents
-Preparation of Mesoporous Materials with Nonhydrocarbon Surfactants
-Worm-like Micelles in Diluted Mixed Surfactant Solutions: Formation and Rheological Behavior

For surface, physical and polymer chemists, materials scientists, and chemical engineers. .[As taken from Amazon]