Articles by 2012 Nobel Prize in Chemistry Winners

Robert Lefkowitz and Brian Kobilka were awarded the Nobel in chemistry for research that looked at how the body communicates with itself, specifically how chemical messengers floating in the bloodstream are able to trigger tissues and organs to respond.

Listed below are some articles by them available at the ScienceDirect database:

Seven transmembrane receptors A brief personal retrospective
Biochimica et Biophysica Acta 1768, 2007, pp.748 755 – R.J. Lefkowitz

Elevated beta-adrenergic receptor number after chronic propranolol treatment
Biochemical and Biophysical Research Communication, 78 (2) 1977, pp. 720 – 725, – G. Glaubiger, R.J. Lefkowitz

Heterogeneity of adenylate cyclase-coupled ?-adrenergic receptors
Biochemical Pharmacology, 24, 1975, pp 583 590 – R.J. Lefkowitz

The New Biology of Drug Receptors
Biochemical Pharmacology, 38 (18) 1989, pp 2941 2948 – R.J. Lefkowitz, B.K. Kobilka,M.G. Caron

Regulation of ? Adrenergic Receptor Signaling by S-Nitrosylation of G-Protein-Coupled Receptor Kinase 2
Cell, 129, 2007, pp 511522, – E. J. Whalen, M. W. Foster, A. Matsumoto, K. Ozawa, J. D. Violin, L. G. Que, C. D. Nelson, M. Benhar, J. R. Keys, H. A. Rockman, W. J. Koch, Y. Daaka, R. J. Lefkowitz, J.S. Stamler

The Beta-Adrenergic Receptor
Life Sciences, 18, 1976, pp 461-472 – R. J. Lefkowitz

Human cardiac beta-adrenergic receptors subtype heterogeneity delineated by direct radioligand binding
Life Sciences, 33. 1983, pp 467-473 – G. L. Stiles, S. Taylor, R. J. Lefkowitz

Historical review: A brief history and personal retrospective of seven-transmembrane receptors
Trends in Pharmacological Sciences, 25 (8) 2005 – R. J. Lefkowitz

G protein coupled receptor structure and activation
Biochimica et Biophysica Acta 1768, 2007, pp 794 807 – B. K. Kobilka

Structure-based drug screening for G-protein-coupled receptors
Trends in Pharmacological Sciences, 33 (5), 2012, pp 268-72 – Brian K. Shoichet, Brian K. Kobilka

Structural insights into adrenergic receptor function and pharmacology
Trends in Pharmacological Sciences, 32 (4) 2011, pp 213-18 – B. K. Kobilka

Ligand-Specific Interactions Modulate Kinetic, Energetic, and Mechanical Properties of the Human ?2 Adrenergic Receptor
Structure, 20 (8) 2012, pp 1391-1402 – M. Zocher, J.J. Fung, B.K. Kobilka, D. J. Müller

Leave a Reply

Your email address will not be published. Required fields are marked *

+ 83 = 91

You may use these HTML tags and attributes: <a href="" title=""> <abbr title=""> <acronym title=""> <b> <blockquote cite=""> <cite> <code> <del datetime=""> <em> <i> <q cite=""> <strike> <strong>