Assistant Professor Sanjay Haresh Chotirmall graduated from the Royal College of Surgeons in Ireland (RCSI) with an honours degree and the colleges’ gold medal in Microbiology. He completed his clinical training in Respiratory and Critical Care Medicine across multiple hospital sites in the Republic of Ireland. As a clinician-scientist, his research interests include microbiome medicine, respiratory and critical care including in particular pulmonary infections.
I focus on translational respiratory based research that aims to take questions from the bedside, answered at the bench with a return to implementation at the bedside. I hope to improve patient care and outcomes particularly in Asian populations where little research on lung disease has been performed to date. Applying multi-omic technologies and endophenotyping to achieve precision medicine implementation for respiratory and infectious disease is a key area of interest and application in my laboratory.
Precision respiratory medicine to get the right treatments to the right patient at the right time
Chotirmall SH, Smith SG, Gunaratnam C, Cosgrove S, Dimitrov BD, O’Neill SJ, Harvey BJ, Greene CM, McElvaney NG.Effect of estrogen on pseudomonas mucoidy and exacerbations in cystic fibrosis. N Engl J Med. 2012 May 24;366(21):1978-86. doi: 10.1056/NEJMoa1106126. Epub 2012 May 20
*Seminal description of an interaction between Pseudomonas aeruginosa and the female sex hormone estrogen
Mac Aogáin M, Tiew PY, Lim AYH, Low TB, Tan GL, Hassan T, Ong TH, Pang SL, Lee ZY, Gwee XW, Martinus C, Sio YY, Matta SA, Ong TC, Tiong YS, Wong KN, Narayanan S, Au VB, Marlier D, Keir HR, Tee A, Abisheganaden JA, Koh MS, Wang Y, Connolly JE, Chew FT, Chalmers JD, Chotirmall SH. Distinct “Immunoallertypes” of Disease and High Frequencies of Sensitization in Non-Cystic Fibrosis Bronchiectasis. Am J Respir Crit Care Med. 2019 Apr 1;199(7):842-853. doi: 10.1164/rccm.201807-1355OC.
*First identification of a bronchiectasis endo-phenotype
Niederman MS, Richeldi L, Chotirmall SH, Bai C. Rising to the Challenge of the Novel SARS-coronavirus-2 (SARS-CoV-2): Advice for Pulmonary and Critical Care and an Agenda for Research. Am J Respir Crit Care Med. 2020 Mar 23. doi: 10.1164/rccm.202003-0741ED.
*Invited commentary to address the international respiratory and critical care community in light of the SARS-CoV-2 pandemic
Use of lung organoids to study COVID-19 pathogenesis (NMRC COVID grant 2020)
The role of Neisseria as a novel respiratory pathogen (NMRC CS-IRG grant 2019)
The pulmonary mycobiome in chronic respiratory disease (NMRC TA grant 2016)
Multiple collaborations throughout Singapore and internationally and academic lead for “The Academic Respiratory Initiative for Pulmonary Health (TARIPH) at LKCMedicine” (see: http://www.lkcmedicine.ntu.edu.sg/Research/TARIPH/Pages/About-TARIPH.aspx)
Research exists for patients not vice versa
Principal Investigator, Translational Respiratory Research Laboratory, Lee Kong Chian School of Medicine
|GOAL 3: GOOD HEALTH AND WELL-BEING – Ensuring healthy lives and promoting the well-being for all at all ages is essential to sustainable development.|
|GOAL 10: REDUCED INEQUALITIES – To reduce inequalities, policies should be universal in principle, paying attention to the needs of disadvantaged and marginalized populations.|
|GOAL 17: PARTNERSHIPS – Revitalize the global partnership for sustainable development.|