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Kimberly Kline
Associate Dean (Faculty)
School of Biological Sciences
College of Science

Kimberly Kline earned her BA in Biology from St. Olaf College in Northfield Minnesota, and received an MPH in Biostatistics and Epidemiology and PhD in Microbiology and Immunology from Northwestern University in 2005. Kimberly went on as a postdoctoral fellow at Washington University in St. Louis and at the Karolinska Institute in Stockholm Sweden. During her training, Kimberly was an American Heart Association Fellow and Carl Tryggers Fellow. Kimberly has received multiple awards for her contributions to the field of microbiology, including a NIH K99 Career Development Award in 2011.

In 2011, Kimberly joined Nanyang Technological University in Singapore as an Assistant Professor of Microbiology and a Principal Investigator at the Singapore Centre for Environmental Life Sciences Engineering, where she leads an international team of 20 research scientists. She was promoted to Associate Professor in 2017. Since coming to Singapore, Kline has been the recipient of the Singapore National Research Foundation Fellowship in 2011, the ICAAC Young Investigator Award from the American Society of Microbiology in 2014, and the Nanyang Education Award in 2017.

Research interests in the Kline lab center around 2 themes: 1) molecular mechanisms of cell-wall associated virulence factor assembly in Gram positive pathogens, and 2) pathogenesis of polymicrobial infections, with an emphasis on those involving Enterococcus faecalis. The Kline lab employs a variety of model systems for these studies including in vitro mammalian cell-associated biofilm models, and mouse models of gut colonization, ascending and catheter-associated urinary tract infection, and wound infections.

Publications
  • Thappeta KR, Vikhe YS, Yong AMH, Chan Park MB, Kline KA. (2020). Combined efficacy of a novel antimicrobial cationic peptide polymer with conventional antibiotics to combat multi-drug resistant pathogens. *Authors contributed equally. ACS Infectious Disease.
  • Ch’ng JH, Chong KKL, Lam LN, Wong JJ, Kline KA. (2019). Biofilm-associated infection by Enterococci. Nature Reviews Microbiology. Nature Reviews. Microbiology.
  • Antonoplis AS, Huttner MA, Zang X, Chong KKL, Bin LY, Co J, Amieva MR, Kline KA, Wender PA, Cegelski L. (2018). Vancomycin coupled to a GR-MoTr exhibits new activity and efficacy against clinically important MRSA biofilms and persister cells. Journal of the American Chemical Society, .
  • Matysik A and Kline KA. (2019) Streptococcus pyogenes capsule promotes microcolony-independent biofilm formation. Journal of Bacteriology.
  • Keogh D, Lam LN, Doyle L, Matysik A, Pavagadhi S, Umashankar S, Low PM, Dale J, Song Y, Ng SP, Boothroyd CB, Dunny G, Swarup S, Williams RBH, Marsili E, Kline KA. (2018) Extracellular electron transfer in Enterococcus faecalis biofilm metabolism. mBio.
Latest Projects
  • A Molecular Blueprint For Iron Sensing In Enterococcal Pathogenesis
  • Designed Short Cyclic Peptides As Antibiotics Potentiator And Wound Healing Platform Against Drug Resistant Gram Negative Bacteria
  • Development of an Infection-Resistant Urinary Catheter Functionalized by Antimicrobial Peptides
  • Imaging the metabolomic biogeography of biofilm-associated wound infection
  • Investigating the Role of HtrA Protease in Antimicrobial-Resistant Gram-Positive Infections
  • Localized Virulence Factor Assembly in Gram Positive Bacteria: Mechanism of Coordination and Therapeutic Targeting
  • Manipulation Of Innate Immune Response By Mucosal BacterialPathogens
  • Mechanisms Of Group A Streptococcus Biofilm Formation On Mammalian Cells
  • Mechanisms of Enterococcal Niche Modulation during Polymicrobial Infection
  • Selective contact-active antimicrobial bio-macromolecules
  • The Cell Biology of Enterococcus faecalis Infection
  • The Promotion of Women in Engineering, Research and Science (POWERS)
  • The roles of Enterrococcus Faecalis Anionic Phospholipids, Glycolipids and Polyisoprenoid Lipids in Membrane Microdomains and Antibiotic Susceptibility
  • Understanding biofilm-associated infections
  • Understanding the pathways for colonisation and infection with Escherichia coli sequence type 131
Other affiliation(s)

Principal Investigator, Singapore Centre on Environmental Life Sciences Engineering

Expert Areas
Antimicrobial Resistance, Biofilms, Infection Biology, Microbiology

Research Interests
Cell-wall, Enterococcus faecalis, Gram positive pathogens, Molecular mechanisms, Pathogenesis, Polymicrobial infections, Virulence factor

Research Category
Life Sciences & Biomedicine
Research Sub-category
Biomedical Sciences & Life Sciences
NISTH Assigned Topic Groupings
Tele-health, medicine, rehab & therapeutics
Affiliated Sustainable Development Goals
GOAL 3: GOOD HEALTH AND WELL-BEING – Ensuring healthy lives and promoting the well-being for all at all ages is essential to sustainable development.
GOAL 5: GENDER EQUALITY – Gender equality is not only a fundamental human right, but a necessary foundation for a peaceful, prosperous and sustainable world.
GOAL 11: SUSTAINABLE CITIES AND COMMUNITIES – There needs to be a future in which cities provide opportunities for all, with access to basic services, energy, housing, transportation and more.
The Sustainable Development Goals (SDGs), also known as the Global Goals, were adopted by all United Nations Member States in 2015 as a universal call to action to end poverty, protect the planet and ensure that all people enjoy peace and prosperity by 2030.
Last Updated
05 May 2020
Last Updated
13 Sep 2020