Retrofitting Sheds Light on Biosynthesis of Anticancer Compound

Retrofitting Sheds Light on Biosynthesis of Anticancer Compound

A team of scientists, led by NTU School of Biological Sciences Prof Liang Zhao Xun, have demonstrated how the study on a family of recently discovered microbial metabolite, sungeidines, yielded unprecedented insights into the biosynthetic steps leading to the formation of anthraquinone-fused enediynes (AQEs)’ structure. The knowledge on the biosynthesis of AQEs will enable scientists to engineer the biosynthetic pathway to generate more potent and less toxic AQE derivatives for targeted cancer therapies.

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