Publications

2020

  • He S, Chou HT, Matthies D, Wunder T, Meyer MT, Atkinson N, Martinez-Sanchez A, Jeffrey PD, Port SA, Patena W, He G, Chen VK, Hughson FM, McCormick AJ, Mueller-Cajar O, Engel BD, Yu Z, Jonikas MC. The structural basis of Rubisco phase separation in the pyrenoid. Nat Plants. 2020 Dec;6(12):1480-1490. (Link)
  • Wunder T, Mueller-Cajar, O. Biomolecular condensates in photosynthesis and metabolism. Current Opinion in Plant Biology (58)1-7 2020 (Link)
  • Ng J, Guo Z, Mueller-Cajar O. (2020). Rubisco activase requires residues in the large subunit N-terminus to remodel inhibited plant Rubisco. Journal of Biological Chemistry 2020 (Link)
  • Davidi, D., Shamshoum, M., Guo, Z., Bar-On, Y. M., Prywes, N., Oz, A., Jablonska, J., Flamholz, A., Wernick, D. G., Antonovsky, N., de Pins, B., Shachar, L., Hochhauser, D., Peleg, Y., Albeck, S., Sharon, I., Mueller-Cajar, O., & Milo, R. Highly active rubiscos discovered by systematic interrogation of natural sequence diversity. The EMBO journal, e104081. Advance online publication, 2020 (Link)
  • Tsai YC, Ye F, Liew L, Liu D, Bhushan S, Gao YG, Mueller-Cajar O. Insights into the mechanism and regulation of the CbbQO-type Rubisco activase, a MoxR AAA+ ATPase.  Proc Natl Acad Sci U S A. 117(1) 381-387, 2020 (Link)

2019

  • Shivhare D, Ng, J, Tsai YC, Mueller-Cajar, O. Probing the rice Rubisco-Rubisco activase interaction via subunit heterooligomerization. Proc Natl Acad Sci U S A. 116(48) 24041-24048, 2019 (Link)
  • Atkinson N, Velanis CN, Wunder T, Clarke DJ, Mueller-Cajar O, McCormick AJ. The pyrenoidal linker protein EPYC1 phase separates with hybrid Arabidopsis-Chlamydomonas Rubisco through interactions with the algal Rubisco small subunit. J Exp Bot 70(19):5271-5285, 2019 (Link)
  • Wunder T, Oh ZG, Mueller-Cajar O. CO2-fixing liquid droplets: Towards a dissection of the microalgal pyrenoid. Traffic 20(6):380-389, 2019 (Link)

2018

  • Wunder T, Cheng SLH, Lai SK, Li HY, Mueller-Cajar O. The phase separation underlying the pyrenoid-based microalgal Rubisco supercharger. Nat. Commun. 9(1):5076 , 2018 (Link)
  • Mueller-Cajar O. Overexpressing the most abundant enzyme. Nat. Plants. 4(10):746-747, 2018 (Link)

2017

  • Bhat JY, Miličić G, Thieulin-Pardo G, Bracher A, Maxwell A, Ciniawsky S, Mueller-Cajar O, Engen JR, Hartl FU, Wendler P, Hayer-Hartl M., Mechanism of Enzyme Repair by the AAA(+) Chaperone Rubisco Activase. Mol Cell. 67(5):744-756, 2017 (Link)
  • Liu D, Ramya RCS, Mueller-Cajar O., Surveying the expanding prokaryotic Rubisco multiverse. FEMS Microbiol Lett. 364(16), 2017 (Link)
  • Mueller-Cajar O., The diverse AAA+ Machines that Repair inhibited Rubisco Active Sites. Front Mol Biosci. 4:31, 2017 (Link)
  • Shivhare D, Mueller-Cajar O., In vitro characterization of thermostable CAM Rubisco activase reveals a Rubisco interacting surface loop. Plant Physiol. 174(3):1505-1516, 2017 (Link)

2016

  • Loganathan N, Tsai YC, Mueller-Cajar O., Characterization of the heterooligomeric red-type rubisco activase from red algae. Proc Natl Acad Sci U S A. 113(49):14019-14024, 2016 (Link)
  • Jin S, Sun J, Wunder T, Tang D, Cousins AB, Sze SK, Mueller-Cajar O., Gao YG. Structural insights into the LCIB protein family reveals a new group of β-carbonic anhydrases. Proc Natl Acad Sci U S A. 113(51):14716-14721, 2016 (Link)

2014-2015

  • Tsai Y.C., Lapina M.C., Bushan S., Mueller-Cajar O., Identification and characterization of multiple rubisco activases in chemoautotrophic bacteria. Nature Communications. 6:8883, 2015 (Link)
  • Durão P, Aigner H, Nagy P, Mueller-Cajar O, Hartl FU, Hayer-Hartl M., Opposing effects of folding and assembly chaperones on evolvability of Rubisco. Nature Chemical Biology 11(2):148-55, 2015
  • Joshi J, Mueller-Cajar O, Tsai YC, Hartl FU, Hayer-Hartl M., Role of Small Subunit in Mediating Assembly of Red-type Form I Rubisco. Journal of Biological Chemistry 290(2):1066-74, 2015
  • Mueller-Cajar O., Stotz M., Bracher A.,  Maintaining photosynthetic CO2 fixation via protein remodelling: the Rubisco activases. Photosynth Res. 119(1-2):191-201, 2014

Graduate and Postdoctoral work

  • Tsai Y., Mueller-Cajar O., Saschenbrecker S., Hartl F. U. and Hayer-Hartl M., The Chaperonin Co-factors Cpn10 and Cpn20 of Chlamydomonas reinhardtii Function as Hetero-oligomeric Ring Complexes. Journal of Biological Chemistry 287(24):20471-81, 2012
  • Mueller-Cajar O., Stotz M., Wendler P., Hartl F. U., Bracher A. and Hayer-Hartl M., Structure and function of the AAA+ protein CbbX, a red-type Rubisco activase. Nature 479: 194-199, 2011
  • Stotz M., Mueller-Cajar O., Ciniawsky S., Wendler P., Hartl F.U., Bracher A. and Hayer-Hartl M., Structure of green-type Rubisco activase from tobacco. Nature Structural and Molecular Biology 18 (12):1366-70, 2011
  • Mueller-Cajar O., Whitney S.M., Directing the evolution of Rubisco and Rubisco activase: first impressions of a new tool for photosynthesis research. Photosynthesis Research 98 (1-3):667-75, 2008
  • Mueller-Cajar O., Whitney S.M., Evolving improved Synechococcus Rubisco functional expression in Escherichia coli.Biochemical Journal 414(2):205-214, 2008
  • Mueller-Cajar O. and Badger M.R., New Roads lead to Rubisco in Archaebacteria. Bioessays 29(8):722-724, 2007
  • Mueller-Cajar O., Morell M. and Whitney S.M., Directed evolution of Rubisco in Escherichia coli reveals a specificity-determining hydrogen bond in the Form II enzyme. Biochemistry 46(49):14067-14074, 2007