About Us

We are interested in the molecular, structural, and functional organisation of polarised epithelial cells. Our current focus is to understand how the the epithelial polarity complexes Par (Par3, Par6, aPKC) and Crumbs (Crb3, Pals1, PatJ) function to control epithelial apico-basal polarity. These protein assemblies are critical for epithelial polarity development and tissue morphogenesis; they control the formation of tight and adherens junctions, membrane trafficking, the cell cytoskeleton, and cell signaling pathways that regulate epithelial cell proliferation. To address how the Par and Crumbs complexes regulate these processes we are applying a combination of genetic, cell biological, biochemical, and structural approaches, as well as imaging by light and electron microscopy.

The ALab is affiliated with the School of Biological Sciences (SBS) at NTU Singapore. Our lab and offices are located at the NTU Institute of Structural Biology (NISB).