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Interactive spatio-molecular map of the apical-lateral border. Shown is a scatter plot of a proximity proteome of a Par3-Pals1 APEX2-SILAC pair. Tight junctions (TJ), adherens junctions (AJ), apical and lateral compartment markers are spatially resolved. Proteins identified apical of TJ exhibit negative log2(H/L) ratios, while proteins identified basal of tight junctions exhibit positive log2(H/L) ratios. Proteins and protein categories can be selected from the dropdown menus. Multiple proteins and protein categories can be displayed simultaneously. The median distributions of selected protein categories are displayed as box plots. Placing the cursor on a given protein displays the protein’s gene name, normalized average log2(H/L) ratio, and average peptide intensity. See Tan et al., 2020: doi: https://doi.org/10.1016/j.cub.2020.05.032
Spatially resolved interactome of the apical-lateral border. The protein network is composed of 335 proteins and is based on the overlap between a Par3-Pals1 APEX2-SILAC pair (see above) and previously published ZO-1 and E-Cadherin proteomes (Van Itallie et al., JBC 2013, Van Itallie et al., JCS 2014). Protein interactions were retrieved from BioGRID and STRING databases and drawn in Cytoscape. Proteins are ranked from top (apical) to bottom (lateral/basal) based on their measured log2(H/L) SILAC ratios in the Par3-Pals1 proteome. See Tan et al., 2020: doi: https://doi.org/10.1016/j.cub.2020.05.032
