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Our lab locates at School of Biological Science (SBS), Nanyang Technological University  (NTU), Singapore. 


The primary research interest of my laboratory is to understand the molecular mechanisms by which the intracellular scaffolding systems, including actin cytoskeleton and plasma membrane, sense and feedback regulate the intrac- and extra-cellular signals, during fungal growth and host-pathogen interactions via the process of macromolecular condensation.The primary research interest of my laboratory is to understand the molecular mechanisms by which the intracellular scaffolding systems, including actin cytoskeleton and plasma membrane, sense and feedback regulate the intrac- and extra-cellular signals, during fungal growth and host-pathogen interactions via the process of macromolecular condensation. We have two main directions. First, we are particularly interested in how the intrinsically disordered regions (IDRs) within ABPs perceive the signals to trigger re-organization of actin assembly, by regulating the protein dynamics, protein conformation, and multivalent protein interactions of ABPs. In the much crowd intracellular environment, actin-binding proteins (ABPs) precisely regulate the dynamics assembly and re-organization of actin networks, in cooperative and competitive manners. How actin polymerization was fine-tuned under different physiological and pathological conditions remain unclear. Second, the actin cytoskeleton networks underneath the plasma membrane control the dynamic molecular behaviors and biochemical activities of cell surface signaling molecules. Our current efforts are trying to understand how actin networks regulate host immunity during plant host-pathogen interactions.

Actin-Yeast  Metaphase actin-3 

  rootMovie

Actin cytoskeleton in budding yeast and Arabidopsis (3D structured illumination microscopy