Our lab locates at School of Biological Science (SBS), Nanyang Technological University (NTU), Singapore. We are also part of School of Chemical and Biomedical Engineering (SCBE), NTU.
We are interested in the both the fundamental mechanisms of actin cytoskeleton assembly and actin assembly supported physiological and pathological processes in eukaryotic cells.
Dynamic assembly of the actin into distinct filament networks, including branched and unbranched actin structures, is necessary for many biological processes in diverse eukaryotes. Assembly of actin filaments into desired architectures needs multiple steps, including nucleation, elongation, crosslinking and depolymerization. We are interested in understanding the mechanisms by which different actin binding proteins (ABPs) receive cellular signals and are then regulated by post-translational modifications to assemble different architectures of actin networks under various physiological or pathological conditions. Our current research mainly focuses on above questions using model species budding yeast and Arabidopsis.
Super-resolution 3D–SIM of Actin cytoskeleton in budding yeast and Arabidopsis