© The Author(s) (European Molecular Biology Organization) Posted on May 17, 2013 by SCG DR Copyright Holders: © The Author(s) (European Molecular Biology Organization) Self-archiving policy Conditions Accepted version: √ Open Access Published version: √ Open Access Remarks: Molecular Systems Biology and EMBO Molecular Medicine Articles are published under Creative Commons Licence without embargo. Users are free to share(copy, distribute and transmit) in the manner specified by the author or licensor. Verification Date: 11.03.2013 22.05.2013